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Cognitive Control clinical trials at UCSD
1 research study open to eligible people

  • Measuring Plasticity in SFC/dACC Following Theta-Burst-Stimulation Using TMS

    open to eligible people ages 18-40

    This is a study to determine whether particular forms of brain-stimulation, applied to superior frontal cortex/preSMA can affect cognition and associated frontal theta oscillations. To perform this study, the investigators will first measure brain activity/cognitive performance using "BrainE", a rapid series of cognitive tests measuring sustained attention, behavioral inhibition, working memory and interference/distractor processing. Next, the investigators will apply brain-stimulation over a mid-frontal region most strongly associated with these tasks (mid-line frontal activity overlying superior frontal cortex/pre-SMA area). Finally, human subjects will perform BrainE assessments again immediately after the brain-stimulation. The investigators will compare the effects of brain stimulation on frontal activity evoked on the cognitive tasks, and on behavioral performance across these tasks. The investigators will further compare two types of brain-stimulation against each other: continuous Theta-Burst-Stimulation (a stimulation protocol designed to inhibit brain activity) and intermittent Theta-Burst Stimulation (a protocol designed to excite brain activity).

    La Jolla, California

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