for people ages 18 years and up (full criteria)
at San Diego, California and other locations
study started
estimated completion



The purpose of this study is to find out if burn injured patients do better receiving fewer blood transfusions than what is traditionally given. We traditionally provide blood transfusions to maintain a hemoglobin level, which is an indicator of the level of red blood cells that carry oxygen in your body, to above 10 g/dl (g/dl stands for grams per deciliter and is the standard measurement used to indicate the level of red blood cells in your blood). However, a preliminary study indicated that maintaining the hemoglobin level to above 7-8 g/dl with less blood transfusion, as compared to a hemoglobin level of 10 g/dl and above, would reduce the occurrence of blood infection, duration on the respirator and length of hospital stay, yet would achieve similar survival in both groups.

Official Title

A Randomized Clinical Trial of Restrictive vs. Traditional Blood Transfusion Practices in Burn Patients


Burn Injury Burn Transfusion blood hemoglobin Burns Benzocaine Restrictive transfusion threshold Liberal transfusion threshold Liberal Restrictive


You can join if…

Open to people ages 18 years and up

  • >20% TBSA burn with anticipated operation need on admission as determined by attending physician
  • age >18 years
  • Admission within 96 hours of injury

You CAN'T join if...

  • <18 years of age
  • pregnancy
  • inability or unwillingness to receive blood products
  • history of chronic anemia (hemoglobin <9.0 g/dL one month prior to enrollment)
  • preexisting need for hemodialysis
  • brain death or imminent brain death
  • non-survivable burn as determined by the attending burn surgeon
  • angina or acute myocardial infarction
  • preexisting hematologic disease
  • Length of hospital stay anticipated to be < 2 weeks
  • Transfusion administered at outside hospital before admit


  • University of California, San Diego
    San Diego California 92103 United States
  • Arrowhead Regional Medical Center
    Colton California 92324 United States


in progress, not accepting new patients
Start Date
Completion Date
American Burn Association
Phase 3
Study Type
Last Updated