Summary

for people ages 30-86 (full criteria)
at La Jolla, California and other locations
study started
estimated completion:

Description

Summary

This study is designed to assess the efficacy, safety and tolerability of ixmyelocel-T compared to placebo (vehicle control) when administered via transendocardial catheter-based injections to patients with end stage heart failure due to IDCM, who have no reasonable revascularization options (either surgical or percutaneous interventional) likely to provide clinical benefit.

Official Title

Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy, Safety and Tolerability of Transendocardial Injection of Ixmyelocel-T in Subjects With Heart Failure Due to Ischemic Dilated Cardiomyopathy (IDCM).

Details

The primary objective of this study is to evaluate the efficacy of ixmyelocel-T compared to placebo (vehicle control) on the average per patient number of all-cause deaths, cardiovascular hospital admissions, and unplanned outpatient or emergency department visits to treat acute decompensated heart failure, over the 12 months following administration of investigational product (IP).

Keywords

Ischemic Dilated Cardiomyopathy (IDCM) Ischemic dilated cardiomyopathy Heart failure ixCELL ixCELL DCM IDCM DCM stem cells MSC cell therapy Ischemia Cardiomyopathies Cardiomyopathy, Dilated ixmyelocel-T

Eligibility

You can join if…

Open to people ages 30-86

  1. Males and non-pregnant, non-lactating females;
  2. Age 30 to 86 years of age;
  3. Diagnosis of ischemic dilated cardiomyopathy;
  4. LVEF ≤ 35% by echocardiogram;
  5. Symptomatic heart failure in NYHA functional class III or IV;
  6. Subject is not a candidate for reasonable revascularization procedures that will produce clinical improvement;
  7. Subject is receiving appropriate clinical standard of care heart failure therapy, as tolerated and as dictated by a subject's current medical condition, for at least 30 days prior to screening;
  8. Must have an automatic implantable cardioverter defibrillator (AICD);
  9. Worsening heart failure hospitalization or equivalent within 6 months prior to screening, hospitalization equivalent defined as an unplanned outpatient/emergency department visit for treatment of acute decompensated heart failure; or have an N-terminal prohormone B-type natriuretic peptide (NT-proBNP) ≥2000 pg/mL or BNP ≥400 pg/mL within 30 days of screening (including screening); or have a 6-minute walk test(6MWT) distance of ≤400 meters at screening;
  10. . Life expectancy of at least 12 months in the opinion of the Investigator;
  11. . LV wall thickness ≥ 7mm (by echocardiogram) at anticipated target injection area;
  12. . Hemodynamic stability without IV vasopressors or support devices;
  13. . Given medical history and concurrent medication, subject is an acceptable candidate for bone marrow aspiration and cardiac catheterization and transendocardial injection procedures in the opinion of the Investigator;
  14. . Willing and able to comply scheduled visits and tolerate study procedures.
  15. . Voluntarily provide a personally-signed and dated informed consent.

You CAN'T join if...

Disease-specific:

  1. Severe primary valvular heart disease including, but not limited to, aortic valve stenosis and insufficiency;
  2. VAD implantation, heart transplantation, cardiomyoplasty, left ventricular reduction surgery, or cardiac shunt implantation;
  3. Planned heart failure-related device interventions (e.g., VAD implantation, initial cardiac resynchronization therapy) or planned cardiac procedures (e.g., heart transplant, cardiomyoplasty, valvular repair);
  4. Current arrhythmias that would prohibit accurate NOGA® electromechanical mapping and NOGA®-guided injections;
  5. LV thrombus (as documented on echocardiography or LV angiography);
  6. Myocardial infarction, stroke or transient ischemic attack within 3 months prior to screening;
  7. Percutaneous coronary intervention, valvuloplasty, cardiac surgery, and other major cardiac procedure within 30 days prior to screening;
  8. In the opinion of the Investigator, the subject's left ventricular wall is unsuitable for transendocardial injections (due to thickness or other reasons).

Medical History:

  1. Stroke or transient ischemic attack (TIA) within 3 months of screening;
  2. . Hemoglobin A1c (HbA1c) ≥ 9% at screening;
  3. . Diabetic subjects with uncontrolled or untreated proliferative retinopathy as determined by dilated eye exam administered by a qualified eye care professional as per American Diabetes Association guidelines;
  4. . Blood clotting disorder not caused by medication (e.g., thrombophilia);
  5. . Active malignancy (non-basal cell) requiring surgery, chemotherapy, and/or radiation in the past 12 months;
  6. . Drug or alcohol abuse that would interfere with the subject's compliance with study procedures;
  7. . Allergies to any equine, porcine, or bovine products;
  8. . Body mass index (BMI) ≥ 40 kg/m2 at screening;
  9. . Established chronic kidney disease (CKD) requiring dialysis (Stage 5); estimated creatinine clearance < 15 mL/min at screening;
  10. . Subject has allergy or is unable to tolerate cardiac imaging contrast agents; also the inability to get a good quality echocardiogram image at screening (as determined by the imaging core lab).

Laboratory Parameters:

  1. . Abnormal laboratory values (performed at central lab) at screening:
  2. Platelets < 50,000 μL;
  3. Hemoglobin < 9.0 g/dL;
  4. Aspartate aminotransferase/alanine aminotransferase (AST/ALT) > 3 times the upper limit of normal (ULN);
  5. Human immunodeficiency virus 1 (HIV 1), HIV 2, or syphilis positive (rapid plasma reagin [RPR]);
  6. Active hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV) antibodies;
  7. NOTE: Additional lab tests may be performed per local requirements including but not limited to: hepatitis B core antibody, human T lymphotropic virus I/II.

Exclusionary Procedures, Devices, or Medication:

  1. . Subjects receiving anti-angiogenic drugs (e.g., anti-vascular endothelial growth factor [VEGF]);
  2. . Chronic exposure to cytotoxic therapy for oncologic or chronic non-oncologic reasons in the prior 3 months or expected requirement over the course of the study;
  3. . Concurrent participation in another interventional clinical trial or receiving experimental intervention within 30 days of screening or having previously been exposed to Aastrom's ixmyelocel T product or previously received allogeneic cell therapy, autologous cell therapy cultured with animal proteins.
  4. . In the opinion of the Investigator, the subject is unsuitable for cellular therapy or has a food/drug allergy, surgical or medical condition, clinically significant psychiatric disorders, poor nutritional status, or lab abnormality requiring further medical evaluation that may interfere with the investigational product, interfere with the study results' interpretation, interfere with the subject's ability to complete the study or compromise the subject's safety.

Locations

  • UCSD Medical Center
    La Jolla California 92037 United States
  • Scripps Clinic
    La Jolla California 92037 United States

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Vericel Corporation
Links
What is IDCM?
ID
NCT01670981
Phase
Phase 2
Study Type
Interventional
Last Updated
March 2017