Summary

Eligibility
for people ages 12-30 (full criteria)
Location
at La Jolla, California and other locations
Dates
study started
estimated completion
Principal Investigator
Kristin Cadenhead, MD
Photo of Kristin Cadenhead
Kristin Cadenhead

Description

Summary

This is a randomized study to compare Compensatory Cognitive Training (CCT) versus Recreational Therapy (RT) in Latino clinical high risk individuals in the US and Mexico. Study hypotheses: Compared to those who receive RT, study participants receiving CCT will show significant improvement in neurocognition, functional capacity, self-rated functioning and clinical measures.

Details

This is a 12 week randomized study to compare Compensatory Cognitive Training (CCT) versus Recreational Therapy (RT) in Latino clinical high risk individuals in the US and Mexico.

Study participants will be measured 3 times, at baseline, 12 and 24 weeks on all outcome measures. Study hypothesis: Study participants receiving CCT will show significant improvement at 12 and 24 weeks compared to baseline in 1) Neurocognition using the Global Cognitive Index z score derived from the MATRICS neurocognitive domain scores, 2) Functional Capacity as assessed by the UCSD Performance-based Skills Assessment (UPSA/UPSA-Adolescent), 3) Self-Rated Functioning as measured by the Specific Level of Functioning Scale (SLoF) and 4) Clinical symptom ratings as measured by the Scale of Prodromal Symptoms (SOPS) total score when compared to subjects receiving RT training across study time.

Keywords

Clinical High Risk Psychosis Prodromal Schizophrenia Psychotic Disorders Cognitive Training Mental Disorders Schizophrenia and Disorders with Psychotic Features Compensatory Cognitive Training Recreational Therapy

Eligibility

You can join if…

Open to people ages 12-30

  • Meet Clinical High Risk criteria
  • Be of Latino descent
  • Speak Spanish as their preferred language

You CAN'T join if...

  • Concomitant medical or neurological illness
  • Brain injury with loss of consciousness > 30 minutes
  • Current substance abuse (excluding nicotine)
  • IQ < 80
  • High suicidal risk

Locations

  • University of California San Diego
    La Jolla California 92093 United States
  • Instituto Nacional de Neurología y Neurocirugía
    Mexico City Mexico

Lead Scientist at UCSD

  • Kristin Cadenhead, MD
    Dr. Kristin Cadenhead a Professor of Psychiatry at University of California San Diego and an attending physician at both the Veterans Administration and the UCSD Medical Centers. She serves as an Associate Residency Training Director for the Department of Psychiatry and a Clinical Foundations Director for the School of Medicine.

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Diego
ID
NCT02245607
Study Type
Interventional
Last Updated