Summary

for people ages 18-100 (full criteria)
study started
estimated completion:
Robert L. Owens

Description

Summary

Sleep deprivation is known to affect brain function but is often ignored in the sickest patients including those in the intensive care unit after major surgery. In these patients, the levels of melatonin can also be altered. Melatonin is a hormone secreted in the brain that maintains the body's sleep-wake, or circadian, cycle. The investigators want to test whether improving sleep quality affects the risk of developing confusion (delirium) in patients having clot removed from their lung (open heart surgery). In order to improve sleep quality, the investigators will conduct a study of Ramelteon, a medication that mimics the activity of melatonin and measure its effects on levels of melatonin and monitor sleep.

Keywords

Delirium Sleep Deprivation Ramelteon

Eligibility

You can join if…

Open to people ages 18-100

  • Patients with Chronic Thromboembolic Pulmonary Hypertension (CTEPH) who are admitted to UCSD for a planned PTE surgery.
  • Age > 18 years

You CAN'T join if...

  • Pregnancy
  • Cirrhosis of any etiology
  • Current use of any atypical antipsychotic including Fluvoxamine (contra-indicated with Ramelteon)
  • Any contraindication to EEG/Sleep recording
  • Non-English speaking (who are unable to complete delirium questionnaires)

Details

Status
accepting new patients by invitation only
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Diego
ID
NCT02691013
Lead Scientist
Robert L. Owens
Study Type
Interventional
Last Updated
January 3, 2018