Summary

for people ages 50-90 (full criteria)
healthy people welcome
at La Jolla, California and other locations
study started
estimated completion:

Description

Summary

The way the immune system responds to certain PD-related proteins in PD donors compared to the way it responds in persons without or fewer PD related proteins is not well studied and this study aims to analyze the autoimmune response in each group. The study involves a one time visit involving brief questionnaires and a blood draw of 30 mL (approximately 2 tablespoons) to be collected.

Details

The role of the immune response in Parkinson's disease (PD) is controversial. Recent studies show that neurons can present MHC-I (major histocompatibility complex - class 1) molecules and therefore may be susceptible to an attack by immune cells. The investigators anticipate that the results of this study will improve our understanding of the mechanisms of immune mediated neuronal degeneration in PD. Initial results suggest that antigens are presented by neuronal MHC-I in PD, and that this could lead to T-cell mediated neuronal death. The most obvious antigen that could be differentially expressed in PD patients and controls would be alpha-synuclein (-syn): -syn oligomers appear in all Lewy bodies and Lewy neurites and are the hallmark of PD changes in the brain. This study will offer the opportunity to further characterize the immune mediated component of PD, and to continue elucidating the biology that underlies antigen presentation and T-cell cytolytic activity.

Keywords

Parkinson's Disease autoimmunity Parkinson Disease

Eligibility

You can join if…

Open to people ages 50-90

  • Moderate to advanced PD with classic motor features, and must demonstrate two of the following three: rest tremor, rigidity, or bradykinesia
  • Dopaminergic medication benefit (self-reported improvement)
  • Age at recruitment: 50 - 90 years
  • Age at diagnosis > 47
  • PD duration > 3 years
  • Willingness to have genotyping and genetic studies as part of laboratory research

You CAN'T join if...

  • Atypical parkinsonism or other neurological disorders
  • Recent history of cancer (past 3 years)
  • Autoimmune disease (except thyroid disease)
  • On chronic immune-modulatory therapy (e.g. SIT (specific immunotherapy), anti-IgE)
  • Inability to provide informed consent

Locations

  • University of California San Diego School of Medicine
    La Jolla California 92037 United States
  • Rush University Medical Center
    Chicago Illinois 60612 United States

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Columbia University
Links
Michael J Fox Foundation ad for study
ID
NCT02939534
Study Type
Observational
Last Updated