for people ages 60-80 (full criteria)
Healthy Volunteers
healthy people welcome
at La Jolla, California
study started
estimated completion
Principal Investigator
by Jeanne Townsend



This is a planning project with a clinical trial pilot to prepare for a larger fully powered clinical trial. Goals of this pilot project are: to identify and address any modifications of the games required for adaptation to diminished sensory abilities; to optimize training dosage and test timing of retention of effects; and to test and refine the battery of outcome assessments. Primary outcome assessment are tests of attention distraction (subtest from a Useful Field of View Test). This pilot will explore a number of secondary outcome measures including EEG and functional imaging biomarkers of change, measures of general cognitive improvement and measures of function including a driving simulator task.

Official Title

Training Foundational Skills to Enhance Cognition in Older Adults


This is a planning trial to optimize procedures for a larger clinical trial. Participants will be randomized into one of two groups--an active group that has intervention training after initial visit and a wait control group that begins intervention after 12 weeks. All participants will receive in-lab baseline testing including IQ (WASI-II), a medical/psychiatric history questionnaire, a depression screen (Geriatric Depression Scale Short Form) and a pre-training battery that includes selected tests from the NIH toolbox, the Repeatable Battery for Neuropsychological Status (RBANS), a Useful Field of View task (UFOV), a driving simulator task, a dual (motor-cognitive) task, an n-back task with and without distractors(with EEG) and 6 minutes of resting state EEG. Participants will be trained to use the game system and play the game at the pre-training in-lab visit. Participants will be provided with a PC with eye-tracker that has training game software installed. Participants will play intervention training games at home for 8-12 weeks with in-lab assessments (the pre-training battery described above). Participants will be asked to play the training games a minimum of 5 times per week for 30 minutes at a time. Compliance will be monitored daily over a secure internet connection. If a participant has played less than the required time in a given week, a research associate will contact the participant to inquire about potential problems and to encourage the participant to resume or increase training time. The first group of 36 participants will receive post-training assessments at 8 weeks, 12 weeks and 6 months. The second group of 36 participants will have an additional pre-training session with structural and functional imaging and will receive only pre- and post-training assessment.


Cognitive Enhancement Aging Gaze-driven training games


You can join if…

Open to people ages 60-80

  1. age 60-80 years old
  2. not demented
  3. living independently; and (4) fluent in English.

You CAN'T join if...

  1. history of dementia, stroke, head injury involving loss of consciousness
  2. current psychiatric or neurological disorders other than depression/anxiety


  • Research on Autism and Development Lab, UCSD accepting new patients
    La Jolla California 92122 United States

Lead Scientist at UCSD


accepting new patients
Start Date
Completion Date
Jeanne Townsend, PhD
Study Type
Last Updated