for people ages 18 years and up (full criteria)
at La Jolla, California and other locations
study started
estimated completion



This first-in-human study will evaluate the safety and tolerability of ABBV-467 in adult participants with relapsed/refractory multiple myeloma (MM).

Official Title

A First In Human Study of the MCL-1 Inhibitor, ABBV-467


Multiple Myeloma (MM) Cancer Relapse/Refractory Multiple Myeloma Neoplasms, Plasma Cell ABBV-467


You can join if…

Open to people ages 18 years and up

  • Documented diagnosis of multiple myeloma (MM)
  • Measurable disease defined as at least 1 of the following: serum monoclonal protein ≥ 1g/dL or urine M-protein ≥ 200mg/24 hours
  • Relapsed after or are refractory or intolerant to all established MM therapies that are known to provide clinical benefit and locally available
  • Received at least 3 prior lines of therapy including 1 or more immunomodulatory agents, 1 or more proteasome inhibitors, and 1 or more anti-CD38 monoclonal antibodies
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2
  • Adequate hematologic, renal and hepatic function
  • Echocardiogram with ejection fraction ≥ 50% and no other clinically significant findings that would increase the participant's susceptibility to cardiac toxicity

You CAN'T join if...

  • Prior exposure to any targeted MCL-1 inhibitor
  • Antineoplastic therapy (including any cytotoxic, targeted and/or investigational therapy; but not including corticosteroids), within 28 days or 5 half-lives, whichever is shorter, prior to the first dose of study drug and through the last dose of study drug
  • Autologous stem cell transplant within 90 days prior to start of study drug
  • Allogenic stem cell transplant within 180 days prior to start of study drug
  • History of acute or chronic pancreatitis
  • Significant unresolved liver disease


  • UCSD Moores Cancer Center - LaJolla /ID# 210075
    La Jolla California 92093 United States
  • City of Hope /ID# 209786
    Duarte California 91010 United States


not yet accepting patients
Start Date
Completion Date
Phase 1
Study Type
Last Updated