for males (full criteria)
at San Diego, California and other locations
study started
estimated completion



The study will evaluate the safety and efficacy of delandistrogene moxeparvovec gene transfer therapy in non-ambulatory and ambulatory males with DMD. This is a randomized, double-blind, placebo-controlled 2-part study. Participants will be in the study for approximately 128 weeks. All participants will have the opportunity to receive intravenous (IV) delandistrogene moxeparvovec in either Part 1 or Part 2.

Official Title

A Phase 3, Multinational, Randomized, Double-Blind, Placebo-Controlled Systemic Gene Transfer Therapy Study to Evaluate the Safety and Efficacy of SRP- 9001 in Non-Ambulatory and Ambulatory Subjects With Duchenne Muscular Dystrophy (ENVISION)


Duchenne Muscular Dystrophy, Ambulatory, Non-ambulatory, DMD, Gene-Delivery, Pediatric, North Star Ambulatory Assessment (NSAA), Performance of Upper Limb (PUL), Duchenne, Muscular Dystrophies, delandistrogene moxeparvovec


You can join if…

Open to males

  • Definitive diagnosis of DMD based on documented clinical findings and prior genetic testing.
  • Cohort 1 only: Non-ambulatory per protocol specified criteria.
  • Cohort 2 only: Ambulatory per protocol specified criteria and ≥8 to <18 years of age at the time of Screening.
  • Ability to cooperate with motor assessment testing.
  • Stable daily dose of oral corticosteroids for at least 12 weeks prior to Screening, and the dose is expected to remain constant throughout the study (except for modifications to accommodate changes in weight).
  • Recombinant Adeno-Associated Virus Serotype rh74 (rAAVrh74) antibody titers are not elevated as per protocol-specified requirements.
  • A pathogenic frameshift mutation or premature stop codon contained between exons 18 and 79 (inclusive).

You CAN'T join if...

  • Exposure to gene therapy, investigational medication, or any treatment designed to increase dystrophin expression within protocol specified time limits.
  • Abnormality in protocol-specified diagnostic evaluations or laboratory tests.
  • Presence of any other clinically significant illness, medical condition, or requirement for chronic drug treatment that in the opinion of the Investigator creates unnecessary risk for gene transfer.

    Other inclusion or exclusion criteria could apply.


  • Rady Children's Hospital-San Diego accepting new patients
    San Diego California 92123 United States
  • Arkansas Children's Hospital accepting new patients
    Little Rock Arkansas 72202 United States


accepting new patients
Start Date
Completion Date
Sarepta Therapeutics, Inc.
Phase 3 Duchenne Muscular Dystrophy Research Study
Study Type
Expecting 148 study participants
Last Updated