Epilepsy clinical trials at UCSD
7 in progress, 3 open to eligible people
NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)
open to eligible people ages 18-75
This is a multicenter, single arm, open label clinical trial that is designed to test the safety and preliminary efficacy of single administration inhibitory nerve cells called interneurons (NRTX-1001), into both temporal lobes of subjects with drug-resistant bilateral mesial temporal lobe epilepsy.
San Diego, California and other locations
Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
open to eligible people ages 18-75
The purpose of this study is to determine whether BHV-7000 is effective in the treatment of refractory focal epilepsy.
La Jolla, California and other locations
NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))
open to eligible people ages 18-75
This clinical trial is designed to test whether a single image-guided intracerebral administration of inhibitory nerve cells, called interneurons (NRTX-1001), into subjects with drug-resistant unilateral mesial temporal lobe epilepsy (MTLE), with or without mesial temporal sclerosis (MTS), is safe (frequency of adverse events) and effective (seizure frequency). NRTX-1001 comprises human interneurons that secrete a neurotransmitter, gamma-aminobutyric acid (GABA).
San Diego, California and other locations
Cenobamate Open-Label Extension Study for YKP3089C025
Sorry, accepting new patients by invitation only
52 Week Open-Label Safety Study of Cenobamate for Subjects who Complete YKP3089C025 (core study)
La Jolla, California and other locations
Healthy Aging in People With Epilepsy Program
Sorry, not yet accepting patients
The goal of this clinical trial is to develop and test an educational program about dementia in older adults living with epilepsy. The main questions it aims to answer are: 1. Can providing education on healthy aging, chronic disease management, dementia, and modifiable lifestyle dementia risk factors improve dementia knowledge and health literacy among older adults with epilepsy? 2. Can aging related education and resources improve quality of life among older adults with epilepsy? Participants will: - Complete a 12-week group educational program. - Complete pre- and post-program evaluation.
San Diego, California
Long-term Safety and Tolerability of BHV-7000
Sorry, accepting new patients by invitation only
A study to determine if BHV- 7000 is safe and tolerable in adults with refractory focal onset epilepsy
La Jolla, California and other locations
Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer
Sorry, in progress, not accepting new patients
This study will examine the combination of pembrolizumab and tadalafil for safety and efficacy in advanced head and neck cancer.
La Jolla, California
Our lead scientists for Epilepsy research studies include Joseph Califano Jerry J Shih, MD.
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