Clinical Trials Open to Healthy Volunteers

A “healthy volunteer” is someone who doesn't have any major health problems, and takes part in research to test new medicines, devices, or treatments. UCSD offers clinical trials on a wide range of medical conditions. Healthy volunteers can help UCSD researchers make better comparisons to better understand the treatment of diseases.

• Adolescent Master Protocol for Participants 18 Years of Age and Older (AMP Up)

  • study on HIV/AIDS and Immunodeficiency
  • open to healthy people ages 18 years and up

• Alzheimer's Disease Neuroimaging Initiative 4

  • study on Mild Cognitive Impairment and Alzheimer's Disease
  • open to healthy people ages 55-90

• Androgen Effects on the Reproductive Neuroendocrine Axis

  • study on Transgender Health and Reproductive Issues
  • open to healthy females ages 18-35

• ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

  • study on Frontotemporal Lobar Degeneration and Progressive Supranuclear Palsy
  • open to healthy people ages 18 years and up

• ASSESS ALL ALS Study

  • study on Amyotropic Lateral Sclerosis (ALS) and Acute Lymphoblastic Leukemia
  • open to healthy people ages 18 years and up

• Association of Microbiome Patterns With Chronic Opioid Use

  • study on Pain and Opioid Use
  • open to healthy people ages 18 years and up

• Avoidance-driven Decision Making and Learning in Anorexia Nervosa and Bulimia Nervosa

  • study on Bulimia and Anorexia
  • open to healthy females ages 18-39

• Beta-Agonist Versus OnabotulinumtoxinA Trial for Urgency Urinary Incontinence

  • study on Urinary Incontinence
  • open to healthy females ages 18 years and up

• Bevonescein in Patients Undergoing Abdominopelvic Surgery

  • study on Surgery and Nerve Injury
  • open to healthy people ages 18 years and up

• Brain Health Virtual Reality Study

  • study on Aging Problems and Memory Loss
  • open to healthy people ages 50-85

• Brain Mechanisms Supporting Cannabis-induced Pain Relief

  • study on Pain and Cannabis
  • open to healthy people ages 21-65

• Cannabidiol and Tetrahydrocannabinol on Microbiome and Neuroinflammation in HIV

  • study on HIV/AIDS and Cannabis
  • open to healthy people ages 21-70

• Cannabis Effects on Antiretroviral Therapy Pharmacokinetics and Neurotoxicity

  • study on HIV/AIDS and Cannabis
  • open to healthy people ages 18 years and up

• Cannabis Use, Cognition, and the Endocannabinoid System in HIV

  • study on HIV/AIDS and Cannabis
  • open to healthy people ages 18-65

• CMV-specific HIV-CAR T Cells as Immunotherapy for HIV/AIDS

  • study on HIV/AIDS and Cytomegalovirus
  • open to healthy people ages 18 years and up

• Community-engaged Optimization of COVID-19 Rapid Evaluation and TEsting Experiences

  • study on COVID-19
  • open to healthy people

• Comparing Clinical Outcomes of Suture Button Versus Fibulink Fixation for Acute Ankle Syndesmosis Injuries

  • study on Ankle Injuries and Syndesmotic Injuries
  • open to healthy people ages 18 years and up

• Consent for Use of Stored Patient Specimens for Future Testing

  • study on HIV/AIDS
  • open to healthy people

• Continuous Glucose Monitoring in Infants

  • study on Neonatal Hypoglycemia
  • open to healthy people

• Deucravacitinib Safety in Pregnancy

  • study on Psoriasis
  • open to healthy females

• Diagnosing Obstructive Sleep Apnea Using Electromyography of the Muscles of the Mouth

  • study on Sleep Apnea and Sleep Disorders
  • open to healthy people ages 18-80

• Dietary Intervention on Inflammation and Microbiome Composition Post-Colonoscopy

  • study on Colon Polyps and Inflammation
  • open to healthy people ages 18 years and up

• Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

  • study on Alzheimer's Disease and Dementia
  • open to healthy people ages 18-80

• Dosimetry of Tc-99m-Tilmanocept

  • study on Diabetes and Kidney Disease
  • open to healthy people ages 18 years and up

• Dyadic Sleep Health Approach for Persons With Alzheimer's Disease and Caregivers

  • study on Sleep and Alzheimer's Disease
  • open to healthy people ages 18 years and up

• Early Detection of Advanced Adenomas and Colorectal Cancer

  • study on Colorectal Cancer and Colorectal Tumor
  • open to healthy people ages 18 years and up

• Effects of Hypoxic Breathwork

  • study on Hypoxic Breathwork Only and Music and Affirmative Messaging
  • open to healthy people ages 18-45

• Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements

  • study on Contraception and Pain
  • open to healthy females ages 18-50

• Enhancing Capacity in Churches to Implement PA Programs

  • study on Cardiovascular Disease
  • open to healthy females ages 18-65

• Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

  • study on Huntington's Disease
  • open to healthy people ages 18 years and up

• Family Functioning in Obesity Treatment for Mexican Americans

  • study on Obesity
  • open to healthy females ages 18-65

• Family, Responsibility, Education, Support, and Health for Families With a Child With Autism

  • study on Autism and Obesity
  • open to healthy people ages 6-12

• Family, Responsibility, Education, Support, and Health for Food Responsiveness

  • study on Obesity and Weight Management
  • open to healthy people ages 7-12

• Focal Therapy for Localized Prostate Cancer

  • study on Prostate Cancer
  • open to healthy males ages 18 years and up

• Food Aversion in Patients With Anorexia Nervosa

  • study on Anorexia
  • open to healthy females ages 18-55

• Gender Disparities in Voice Outcomes After Tracheoesophageal Puncture in Total Laryngectomy Patients (UC Davis)

  • study on Speech Disorders and Speech Dysfunction
  • open to healthy people ages 18 years and up

• Hybrid Effectiveness-Implementation Trial of an Executive Functioning Intervention for Children's Mental Health Services

  • study on Autism and Executive Functioning
  • open to healthy people ages 6-99

• Implementation of COMPRENDO

  • study on Cancer, General
  • open to healthy people ages 18 years and up

• Incentive Processing and Learning in Anorexia Nervosa and Bulimia Nervosa

  • study on Anorexia and Bulimia
  • open to healthy females ages 18-39

• Kesimpta (Ofatumumab) Pregnancy Registry

  • study on Multiple Sclerosis and Pregnancy
  • open to healthy people ages 18-100

• Ketogenic Diet and Brain Response in Anorexia Nervosa

  • study on Anorexia and Ketogenic Diet
  • open to healthy people ages 18-45

• Lenacapavir and Emtricitabine/Tenofovir Disoproxil Fumarate (F/TDF) for Prevention of HIV in People Who Inject Drugs (HPTN 103)

  • study on HIV/AIDS and PrEP
  • open to healthy people ages 18 years and up

• Lenacapavir and Emtricitabine/Tenofovir Disoproxil Fumarate (F/TDF) in Prevention of HIV in Cisgender Women in the United States (HPTN 102)

  • study on HIV/AIDS and PrEP
  • open to healthy females ages 18 years and up

• Microdosing ICG for Serial Colonic Perfusion Study During Surgery

  • study on Perfusion
  • open to healthy people ages 18-80

• Motivational Interviewing to Increase Uptake of Drug Checking and Safe Drug Use Behaviors to Reduce Overdose

  • study on Overdose
  • open to healthy people ages 18 years and up

• Multi-Omics for Maternal Health After Preeclampsia

  • study on Eclampsia and High Blood Pressure
  • open to healthy females ages 18-50

• Neurophysiologic Biomarkers for Cognitive Rehabilitation

  • study on Schizophrenia
  • open to healthy people ages 18-75

• Next Generation Chest X-Ray Tomosynthesis for Screening of Lung Cancer

  • study on Lung Cancer and Lung Tumor
  • open to healthy people ages 30-85

• North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)

  • study on Mitochondrial Disorders and Mitochondrial Genetic Disorders
  • open to healthy people

• Pancreatic Cancer Early Detection Consortium

  • study on Pancreatic Cancer and Pancreatic Cyst
  • open to healthy people ages 18-90

• PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

  • study on Parkinson's Disease
  • open to healthy people ages 30 years and up

• Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care

  • study on HIV/AIDS and Alcohol Use
  • open to healthy people ages 18 years and up

• Practice-Based Intervention to Improve Care for a Diverse Population of Women with Urinary Incontinence

  • study on Urinary Incontinence
  • open to healthy people ages 18 years and up

• Prevention Ambassadors: Intervention to Promote HIV Service Engagement in the Networks of SSP Clients

  • study on HIV/AIDS
  • open to healthy people ages 18 years and up

• Progestin-only Contraception on Bleeding Patterns in Individuals Initiating GATT

  • study on Gender and Contraception
  • open to healthy people ages 18-50

• Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD

  • study on Post-Traumatic Stress Disorder
  • open to healthy people ages 18-75

• Promoting Physical Activity in Older Hispanic/Latino(a) Adults

  • study on Sedentary Behavior and Physical Inactivity
  • open to healthy people ages 55-89

• Researchers At UC San Diego Are Learning About the Benefits of Human Milk and How It Influences Infant and Child Health

  • study on Breastfeeding and COVID-19
  • open to healthy females ages 18 years and up

• Retrograde Femoral Nail-Advanced Outcomes for Fixation of Distal Femur and Femoral Shaft Fractures

  • study on Femoral Fracture
  • open to healthy people ages 18 years and up

• Statewide System and Organizational Strategy for EBP Implementation

  • open to healthy people ages 18 years and up

• Surveillance Monitoring for ART Toxicities Study in HIV Uninfected Children Born to HIV Infected Women

  • study on Antiretroviral Toxicity
  • open to healthy people

• Systems Analysis and Improvement Approach for Optimizing HIV Service Delivery in Syringe Services Programs

  • study on HIV/AIDS
  • open to healthy people ages 18 years and up

• Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC

  • study on Lung Cancer and Non-Small Cell Lung Cancer
  • open to healthy people ages 18 years and up

• Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

  • study on Amyotropic Lateral Sclerosis (ALS) and Movement Disorders
  • open to healthy people ages 18 years and up

• Test the Effects of Nezavist At Different Doses in Healthy Adults

  • study on Tolerability
  • open to healthy people ages 18-55

• TREAD: Time Restricted Eating Intervention for Alzheimer's Disease

  • study on Mild Cognitive Impairment and Alzheimer's Disease
  • open to healthy people ages 60 years and up

• UCSD RELINK: Connecting Adults To Supportive Services

  • study on Health Care Utilization
  • open to healthy people ages 18 years and up

• Women Focused Encounters for Resilience Independence Strength and Eudaimonia

  • study on HIV/AIDS and Substance Abuse
  • open to healthy females ages 18 years and up

• Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

  • study on Breast Cancer and Cancer, General
  • open to healthy females ages 30-74

Current as of: June 18, 2025