for females ages 18-55 (full criteria)
Healthy Volunteers
healthy people welcome
at La Jolla, California and other locations
study started
completion around
Principal Investigator
by MPM Pei-an (Betty) Shih



This study uses a meal-challenge protocol to assess if patients with anorexia nervosa show a differential metabolism in response to food in comparison to healthy controls. This study determines how heritable and biochemical factors influence food metabolism in anorexia nervosa in order to develop more effective treatment strategies.

Official Title

Solving EPHX2 and Polyunsaturated Fatty Acid Interactions in Anorexia Nervosa


Anorexia nervosa is a brain-based disorder that often leads to serious health consequences including death. The EPHX2 gene has been identified as a susceptibility gene for anorexia nervosa. This study utilizes a multi-omics biomarker system approach to investigate how genetic factors interact with dietary factors to influence food aversion, psychopathology, and clinical outcome in patients with anorexia nervosa.


Anorexia Nervosa, psychopathology, treatment, epoxide hydrolases, polyunsaturated fatty acids, eicosanoids, Anorexia, A breakfast sandwich, Anorexia nervosa I, Anorexia nervosa II


You can join if…

Open to females ages 18-55

  • Ill AN subjects will meet current Diagnostic and Statistical Manual of Mental Disorders (DSM V) diagnosis of AN, body mass index (BMI) between 11 kg/m² and 17.5 kg/m², or BMI > 17.5 kg/m² with active eating disorder symptoms.
  • Recovered AN must meet the following criteria at time of study entry: 1) Current or past DSM V diagnosis of AN; 2) BMI between 18.5 kg/m2 and 30 kg/m2; 3) Having maintained a BMI of >18.5 for at least one year.
  • Control must be healthy adolescent or woman negative on our screen for AN, other Axis I psychiatric illnesses, and having maintained a BMI of between 18.5-30 kg/m² since the age of 18.

You CAN'T join if...

  • Exclusion criteria for AN and control subjects include: Organic brain syndrome, schizophrenia and schizoaffective disorder, untreated thyroid disease, renal disease, hepatic disease, and the regular use of fish-oil containing supplements within the last three months of the study. All pregnant and lactating individuals will be excluded.


  • UC San Diego Altman Clinical and Translational Research Institute accepting new patients
    La Jolla California 92037 United States
  • Program for Eating Disorders, Toronto General Hospital accepting new patients
    Toronto Ontario Canada

Lead Scientist at UCSD


accepting new patients
Start Date
Completion Date
University of California, San Diego
Food Aversion Study For Anorexia Nervosa at University of California, San Diego
Study Type
Expecting 300 study participants
Last Updated