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Graft Versus Host Disease clinical trials at UCSD
3 in progress, 1 open to new patients

  • GRAVITAS-301: A Study of Itacitinib or Placebo in Combination With Corticosteroids for Treatment of Acute Graft-Versus-Host Disease

    open to eligible people ages 18 years and up

    The purpose of this study is to evaluate itacitinib or placebo in combination with corticosteroids as first-line treatment of participants with Grade II to IV acute graft-versus-host disease (aGVHD).

    La Jolla, California and other locations

  • Chronic Graft-versus-Host Disease Treatment (BMT CTN 0801)

    Sorry, in progress, not accepting new patients

    This study is designed as a combined Phase II/III, randomized, open label, multicenter, prospective comparative study of sirolimus plus prednisone versus sirolimus/calcineurin-inhibitor plus prednisone for the treatment of chronic GVHD. Patients will be stratified by transplant center and will be randomized to an experimental arm of one of the two pre-specified experimental arms (sirolimus + prednisone or the comparator arm of sirolimus + calcineurin inhibitor + prednisone) in a 1:1 ratio.

    La Jolla, California and other locations

  • Extended Treatment Protocol for Subjects Continuing to Benefit From Ibrutinib.

    Sorry, not currently recruiting here

    Multicenter, open-label, prospective treatment protocol that provides continued access to ibrutinib to subjects who have completed parent ibrutinib studies, are still benefitting from treatment with ibrutinib, and have no access to commercial ibrutinib for their underlying disease within their region.

    La Jolla, California and other locations