Kidney Stones clinical trials at UCSD

7 in progress, 3 open to eligible people

Showing trials for

  • SOUND Pivotal Trial - (Sonomotion stOne comminUtion resoNance ultrasounD)

    open to eligible people ages 18 years and up

    The goal of this clinical trial is to test the Break Wave™ system in patients with upper urinary tract stones. The main question it aims to answer is whether the device is safe and effective in fragmenting (breaking) stones. Participants will a) undergo the Break Wave™ procedure, b) have a telehealth visit at 2 weeks, and c) return for an imaging study at approximately 10 weeks post-procedure.

    San Diego, California and other locations

  • Thulium Fiber Laser (TFL) vs Thulio Pulsed Thulium:YAG (p-Tm:YAG)

    open to eligible people ages 18 years and up

    This research study is being conducted to assess the ability and efficiency of two laser systems to break up kidney stones during ureteroscopy with laser lithotripsy for kidney stone treatment.

    San Diego, California

  • Asymptomatic Renal Calculi in Recurrent Urinary Tract Infections

    open to eligible people ages 18 years and up

    This study will assess patients who have recurrent urinary tract infections and kidney stones which are not blocking the kidney or causing other problems. Currently, we don't know if taking out these stones will improve recurrent urinary tract infections or not. Patients will make a decision with their surgeon about removing or monitoring their stone(s). Whether or not their infections continue with surgery or monitoring will be noted, and this information may help to inform future treatment decisions. The purpose of this study is to assess if treatment of these asymptomatic stones affects the rate of recurrent urinary tract infections.

    San Diego, California and other locations

  • Break Wave(TM) Extracorporeal Lithotripter First-in-Human Study

    Sorry, in progress, not accepting new patients

    This is a prospective, open-label, multi-center, single-arm (non-randomized) study to assess the safety and effectiveness of breaking stones in the upper urinary tract using the SonoMotion Break Wave technology. Up to 30 subjects will be included. The procedure will be performed in a hospital surgical environment as an outpatient (without being admitted) or in a non-surgical environment such as a clinic or office procedure room. The procedure will be performed under varying levels of anesthesia ranging from no anesthesia to general anesthesia (fully asleep). Stones will be limited to ≤ 10 mm for lower pole stones and ≤ 20 mm everywhere else. Safety will be measured by the self-reported occurrences of adverse events, unplanned emergency department or clinic visits, and the need for further intervention. Fragmentation will be measured by self-reported stone passage and a comparison of computed tomography (CT) images before and after the procedure.

    San Diego, California and other locations

  • Continuous Erector Spinae Plane Blocks to Treat Pain Following Percutaneous Nephrolithotomy

    Sorry, accepting new patients by invitation only

    This is a randomized, triple-masked, placebo-controlled parallel-arm human subjects clinical trial investigating the addition of a continuous erector spinae plane nerve block to a single-injection erector spinae plane block to provide postoperative analgesia following percutaneous nephrolithotomy. Participants will all receive a single-injection nerve block and perineural catheter insertion. Following surgery, participants will be randomly allocated to receive either perineural local anesthetic or normal saline until the second day following surgery.

    San Diego, California and other locations

  • RELIEF™ Ureteral Stent Randomized Controlled Trial

    Sorry, not yet accepting patients

    Assessment of the backwards flow of urine from the bladder into the ureter (retrograde urine reflux) after placement of the RELIEF® Ureteral Stent using imaging of the bladder after filling it with contrast and assigning a urinary reflux grade. Randomized controlled trial for evaluation of the stent placement and the adequacy of short term drainage (defined as the presence of the stent in the ureter and the lack of surgical or standard of care double J stent to treat symptoms associated with the stent itself on the stented side during the first 48 hours).

  • Radiation-Free Percutaneus Nephrolithotomy for Kidney Stones

    Sorry, in progress, not accepting new patients

    The goal of this observational study is to investigate the feasibility of ultrasound-guided percutaneus nephrolithotomy in patients with kidney stones. The main question's it aims to answer are: Does the use of ultrasound in percutaneus nephrolithotomy affect stone free rates, defined by no stone or stone <2mm, on follow up visit? Does the use of ultrasound in percutaneus nephrolithotomy affect complication rates, categorized by Clavien system? Researchers will compare ultrasound-guided percutaneus nephrolithotomy to traditional nephrolithotomy using fluoroscopy to see if outcomes differ. Participants will be chosen for any of the above interventions at surgeon's discretion.

    San Diego, California

Our lead scientists for Kidney Stones research studies include .

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