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KRAS G12C clinical trials at UCSD

2 research studies open to eligible people

Showing trials for
  • FMC-376 in Participants with KRAS G12C Mutated Solid Tumors

    open to eligible people ages 18 years and up

    The goal of this clinical trial is to evaluate FMC-376 in participants with advanced solid tumors with KRAS G12C mutations. This clinical trial will be conducted in 3 parts: Phase 1A (Dose Escalation), Phase 1B (Dose Expansion), and Phase 2 (Cohort Expansion). Multiple dose levels in participants with advanced solid tumors will be evaluated.

    La Jolla, California and other locations

  • BBO-8520 in Adult Subjects with KRASG12C Non-small Cell Lung Cancer

    open to eligible people ages 18 years and up

    A first in human study to evaluate the safety and preliminary antitumor activity of BBO-8520, a KRAS G12C (ON and OFF) inhibitor, as a single agent and in combination with pembrolizumab in subjects with locally advanced and unresectable or metastatic non-small cell lung cancer with a KRAS (Kirsten rat sarcoma) G12C mutation.

    La Jolla, California and other locations

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