Ocular Melanoma clinical trials at UCSD
6 in progress, 5 open to eligible people
(Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma
open to eligible people ages 18 years and up
Neoadjuvant/adjuvant IDE196 (darovasertib) in patients with primary uveal melanoma
La Jolla 5363943, California 5332921 and other locations
Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma
open to eligible people ages 18 years and up
The primary objective is to determine the safety and efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary indeterminate lesions (IL) or small choroidal melanoma (CM).
La Jolla 5363943, California 5332921 and other locations
RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma
open to all eligible people
The purpose of this study is to measure the clinical benefits of the combination of RP2 and nivolumab as compared with the combination of nivolumab and ipilimumab in patients with metastatic uveal melanoma who have not been treated with immune checkpoint inhibitor therapy.
La Jolla 5363943, California 5332921 and other locations
IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma
open to eligible people ages 18 years and up
This is a Phase 2/3, multi-arm, multi-stage, open-label study of human leukocyte antigen (HLA)-A*02:01 negative participants with metastatic uveal melanoma (MUM) who will be randomized to receive either IDE196 + crizotinib or investigator's choice of treatment (pembrolizumab, ipilimumab + nivolumab, or dacarbazine).
La Jolla 5363943, California 5332921 and other locations
Screening Study to Collect Samples for TAA, HLA & HLA Loss of Heterozygosity in Patients With Metastatic Solid Tumors
open to eligible people ages 18 years and up
TScan Therapeutics is developing cellular therapies across multiple solid tumors in which autologous T cells are engineered to express a T cell receptor that recognizes tumor-associated antigens presented on specific Human Leukocyte Antigen (HLA) molecules. The purpose of this screening study is to collect samples to conduct HLA genotyping, HLA Loss of Heterozygosity (LOH) assessment, and expression of Tumor-associated Antigens (TAA) testing. These results will be used to determine if participants meet the eligibility criteria for these parameters and could potentially be enrolled in a TScan clinical study.
San Diego 5391811, California 5332921 and other locations
Neoadjuvant Darovasertib in Primary Uveal Melanoma
Sorry, not currently recruiting here
This is a Phase 3, randomized, multi-center, open-label study of neoadjuvant darovasertib in subjects with primary non-metastatic uveal melanoma (OptimUM-10)
La Jolla 5363943, California 5332921 and other locations
Our lead scientists for Ocular Melanoma research studies include Sandip Patel, MD.
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