Summary

for people ages 18 years and up (full criteria)
healthy people welcome
at La Jolla, California and other locations
study started

Description

Summary

The study intervention consists of the early integration of palliative care services into standard oncology care in an outpatient setting for patients with advanced lung and non-colorectal gastrointestinal malignancies who are not being treated with curative intent. The palliative care services provided to patients randomized to the intervention will be provided by board-certified physicians and/or advanced practice nurses and will focus on the following areas: (1) developing and maintaining the therapeutic relationship with the patients and family caregivers; (2) assessing and treating patient symptoms; (3) providing support and reinforcement of coping with advanced cancer in patients and family caregivers; (4) assessing and enhancing prognostic awareness and illness understanding in patients and family caregivers; (5) assisting with treatment decision-making; and (6) end-of-life care planning.

Official Title

Randomized Study of Early Palliative Care Integrated With Standard Oncology Care Versus Standard Oncology Care Alone in Patients With Incurable Lung or Non-Colorectal Gastrointestinal Malignancies

Details

There will be about 400 patients enrolled in this intervention study and there will be about 300 family caregivers enrolled as well. This study will consist of two study groups as previously described. The effects of the early involvement of the palliative care team will be compared to the usual approach of receiving care mostly from the cancer treatment team. The stratification factors include tumor type (lung vs. esophageal/gastric vs. hepatic/biliary/pancreatic) and family care giver participation (yes vs. no). Patients will be on this study for as long as they receive care. Institutions must have an outpatient palliative care clinic that meets the study site requirements as defined in the protocol. The outpatient clinic leadership must include a physician and/or advanced practice nurses board certified in palliative care. The primary and secondary endpoints are described below.

Primary Endpoint:

To determine the efficacy of early integrated palliative care on patient reported quality of life at 12 weeks using the FACT in patients with newly diagnosed incurable lung or non-colorectal gastrointestinal cancer

Secondary Endpoints:

  • To determine the efficacy of early integrated palliative care on other patient reported outcomes in patients with newly diagnosed incurable lung or non-colorectal gastrointestinal cancer, by assessing the endpoints defined in the protocol
  • To determine the efficacy of early integrated palliative care on family caregiver reported outcomes in those newly diagnosed incurable lung or non-colorectal gastrointestinal cancer, by assessing the endpoints defined in the protocol
  • To assess the impact of early integrated palliative care on the quality of end-of-life care and resource utilization in patients with newly diagnosed incurable lung or non-colorectal gastrointestinal cancer by assessing the endpoints defined in the protocol
  • To determine concordance between patient and family caregiver report of prognosis/ curability

Keywords

Liver Cancer Anxiety Disorder Depression Small Cell Lung Cancer Extrahepatic Bile Duct Cancer Malignant Mesothelioma Pancreatic Cancer Esophageal Cancer Gastric Cancer Non-small Cell Lung Cancer Lung Neoplasms Carcinoma, Non-Small-Cell Lung Pancreatic Neoplasms Stomach Neoplasms Esophageal Neoplasms Small Cell Lung Carcinoma Anxiety Disorders Liver Neoplasms Mesothelioma Bile Duct Neoplasms Cholangiocarcinoma Early palliative care

Eligibility

For people ages 18 years and up

Study Patient Participant Eligibility Requirements:

  1. Documentation of Disease: Confirmed advanced lung cancer (NSCLC, small cell lung cancer, or mesothelioma) or non-colorectal GI cancer (esophageal, gastric, hepatic,biliary, or pancreatic) not being treated with curative intent.
  2. Informed of diagnosis of incurable disease within the previous 8 weeks.
  3. Age ≥ 18 years
  4. ECOG Performance Status 0-2
  5. Ability to read and respond to questions in English or able to complete questions with minimal assistance required from an interpreter or family member.
  6. Planning to receive all medical care for cancer at the enrolling institution.
  7. Participants must be under the care of an oncologist, but their current plan may or may not include chemotherapy or other forms of tumor-directed therapies.

Study Family Caregiver Participant Eligibility Requirements:

  1. Relative or friend who is identified by the patient participant who plans to regularly accompany the patient to the majority of their clinic visits.
  2. Family caregiver must live with the patient or have in-person contact with him or her at least twice per week.
  3. Ability to read and respond to questions in English or able to complete questions with minimal assistance required from an interpreter or family member.
  4. Age ≥ 18 years

Note: An eligible patient may participate in this trial without an eligible family caregiver being registered.

Locations

  • UC San Diego Moores Cancer Center
    La Jolla California 92093 United States
  • University of Oklahoma Health Sciences Center
    Oklahoma City Oklahoma 73104 United States
  • Altru Cancer Center
    Grand Forks North Dakota 58201 United States

Details

Status
in progress, not accepting new patients
Start Date
Sponsor
Alliance for Clinical Trials in Oncology
ID
NCT02349412
Phase
Phase 3
Study Type
Interventional
Last Updated
April 2017