for people ages 3 years and up (full criteria)
at La Jolla, California and other locations
study started
estimated completion
Seema Aceves, M.D., PhD



The purpose of this observational study is to find the best measures to define how well a person with eosinophilic disorder is doing. People with eosinophilic esophagitis (EoE), eosinophilic gastritis (EG), and eosinophilic colitis (EC) normally undergo endoscopy and/or colonoscopy (scope down the throat or up the bottom) where tissue specimens are collected for microscopic analysis. Treatments are then decided based on how the tissue looks. We are aiming to compare different tissue components such as inflammatory cell types with clinical symptoms. We want to see if scores on standard questionnaires can give us an idea how well the person is doing.

Official Title

A Prospective, Multicenter Study to Compare and Validate Endoscopic, Histologic, Molecular, and Patient-Reported Outcomes in Pediatric and Adult Patients With Eosinophilic Esophagitis (EoE), Gastritis (EG) and Colitis (EC)


This is a longitudinal observational study in which individuals (males and females 3 years of age and greater) with EoE, EG, and EC will be followed over the course of time to see if standard questionnaires can give us an idea of how well the person is doing.

Participants undergoing standard of care (normal, routine care) endoscopies and/or colonoscopies will have biopsies (small pieces of tissue from the GI tract normally collected during these procedures) collected and used for the research study. Participants will also complete questionnaires related to their symptoms and quality of life. Participants will be followed over the course of time and asked to complete the questionnaires at various time points throughout the study.


Eosinophilic Gastrointestinal Disorders (EGIDs) Eosinophilic Esophagitis Eosinophilic Gastritis Eosinophilic Colitis Colitis Esophagitis Gastritis Gastrointestinal Diseases Digestive System Diseases


You can join if…

Open to people ages 3 years and up

  • Males or females 3 years of age and older
  • Mucosal eosinophilia (≥15 eos/hpf for EoE, ≥30 eos/hpf for EG, ≥32 eos/hpf for EC)
  • Presence of symptoms is required for patients who are newly diagnosed but not required for patients who were previously diagnosed
  • EC patients must have a history of one of the following at the time of colonoscopy:
  • anemia
  • peripheral eosinophilia
  • hemoccult positive stool
  • EGID
  • allergic disease (allergic rhinitis, asthma, food allergy, eczema or other allergic features suggestive of atopic disease)

You CAN'T join if...

  • History of intestinal surgery other than G tube placement
  • Enrolled in a blinded investigational study
  • Have esophageal stricture (<3mm)
  • Have other identifiable causes for eosinophilia (except Inflammatory Bowel Disease): infections, Gastrointestinal (GI) cancer, other GI inflammatory disease (e.g., Ulcerative Colitis or Crohn's Disease)


  • University of California, San Diego accepting new patients
    La Jolla California 92093 United States
  • University of Utah not yet accepting patients
    Salt Lake City Utah 84112 United States

Lead Scientist

  • Seema Aceves, M.D., PhD
    Dr. Aceves completed both her medical degree and her PhD through the Medical Scientist Training Program at UC San Diego. She also completed her pediatric internship, residency and a fellowship in allergy and immunology at UC San Diego.


accepting new patients
Start Date
Completion Date
Children's Hospital Medical Center, Cincinnati
Learn more about this study at the CEGIR website
Study Type
Last Updated