for females ages 18 years and up (full criteria)
Healthy Volunteers
healthy people welcome
at La Jolla, California and other locations
study started
estimated completion
Principal Investigator
by Sarah Averbach, MD, MAS
Headshot of Sarah Averbach
Sarah Averbach



Intrauterine devices (IUDs) are historically placed at a six-week postpartum visit for women who desire intrauterine contraception after delivery. A two-week postpartum visit could be a convenient time for women to receive contraception, including IUDs. Offering women IUDs at two-weeks postpartum may decrease the risk of undesired pregnancy and rapid repeat pregnancy. This study will compare IUD insertion at two different times after delivery: two-weeks and six-weeks postpartum. This will allow researchers to assess whether the timing of IUD placement affects whether an IUD is expelled, or pushed out of it's ideal location.

Official Title

Early vs. Interval Postpartum IUD Insertion: A Multi-site Randomized Controlled Trial


The purpose of this study is to determine the proportion of IUDs inserted in the Early Postpartum (EPP) period that are expelled at 6 months postpartum. This prospective, multi-site randomized trial will enroll approximately 404 women at three large academic hospitals in the United States. Women will be recruited who are interested in receiving a levonorgestrel-IUD or a copper-IUD after delivery. Postpartum women who desire an IUD will be randomized to EPP IUD insertion (between 14-28 days PP) or interval postpartum IUD insertion (42-56 days PP) and the proportion of IUDs expelled will be compared between groups at 6 months postpartum. All women will be seen in clinic at 6-8 weeks and 6 months postpartum. Women randomized to EPP IUD placement will be seen at 2-3 weeks postpartum. Provider perspectives of EPP IUD placement will also be evaluated, as will whether these attitudes change after 6 to 9 months of providing early postpartum IUDs.


Contraception, Mirena, ParaGard, Skyla, Liletta, Kyleena, Intrauterine Device, Intrauterine System, Postpartum, Expulsion, IUD


You can join if…

Open to females ages 18 years and up

  • Gave birth less than or equal to 10 days ago
  • Desires to use an IUD for Contraception (either copper or levonorgestrel)
  • Willing and able to sign an informed consent
  • Willing to comply with the study protocol
  • Age greater than or equal to 18 years
  • English or Spanish speaking

You CAN'T join if...

  • Uterine anomaly or leiomyomata which would not allow placement of an IUD
  • Desire for repeat pregnancy in less than 6 months
  • Evidence of intrauterine infection (chorioamnionitis or postpartum endometritis) treated with antibiotics
  • Ruptured uterus at the time of delivery
  • Received a postpartum tubal ligation or immediate postpartum IUD or implant at delivery
  • Incarcerated women or women with significant cognitive impairment
  • 4th degree perineal laceration sustained at delivery
  • Any medical contraindication to IUD per the US Centers for Disease Control (CDC) Medical Eligibility Criteria
  • Suspicion for new pregnancy


  • University of California, San Diego
    La Jolla California 92093 United States
  • Naval Medical Center San Diego
    San Diego California 92134 United States

Lead Scientist at UCSD

  • Sarah Averbach, MD, MAS
    Associate Adjunct Professor, Ob/Gyn & Reproductive sciences, Vc-health Sciences-schools. Authored (or co-authored) 48 research publications


in progress, not accepting new patients
Start Date
Completion Date
University of California, San Diego
Study Type
About 404 people participating
Last Updated