for people ages 1-65 (full criteria)
at San Diego, California
study started
completion around
Principal Investigator
by Seema Aceves
Headshot of Seema Aceves
Seema Aceves



Single center observational and specimen banking study for children with eosinophilic esophagitis EoE to gauge natural history and inflammatory markers


Participants with a diagnosis of EoE are recruited from Rady Children's Hospital Eosinophilic Gastrointestinal Disorders (EGID) during routine clinic and/or endoscopy visits.

Medical information including clinical symptoms, endoscopy, histopathology, medical and surgical history, lab and imaging findings, are entered into a UCSD database at each clinic or endoscopy visit. Blood and biopsy specimens are procured and utilized for analysis of inflammatory molecules and for isolation of structural cells. This protocol continues our clinical database and sample collection in children with EoE. The database provides a cohort of EoE patients for studies of natural history, therapeutic response, and disease progression. In a relatively new disease of increasing incidence, these studies will provide information on disease progression and the clinical characteristics of patients who have varying disease phenotypes as well as the associations between clinical phenotypes, molecular changes, and disease course. The procurement and storage of tissue, cells, and serum samples provides a repository for studies of EoE-related molecules and peripheral markers in clinically phenotyped patients. In addition, the study of these esophageal cells will provide an in vitro model system for assessing the molecular mechanisms of disease pathogenesis in EoE.


Eosinophilic Esophagitis, Esophagitis


You can join if…

Open to people ages 1-65

  • Have a known EoE diagnosis
  • Complain of dysphagia, vomiting, or abdominal pain, especially if recalcitrant to acid blocking therapy (but does not have to be recalcitrant to acid blocking medications)
  • Present with food impaction
  • Present with esophageal stricture
  • Have characteristic endoscopic findings of EoE of pallor, linear furrows, lichenification, white plaques, or concentric rings

You CAN'T join if...

  • None


  • Rady Children's Hospital San Diego accepting new patients
    San Diego California 92123 United States

Lead Scientist at UCSD

  • Seema Aceves
    Dr. Aceves completed both her medical degree and her PhD through the Medical Scientist Training Program at UC San Diego. She also completed her pediatric internship, residency and a fellowship in allergy and immunology at UC San Diego.


accepting new patients
Start Date
Completion Date
University of California, San Diego
Study Type
Expecting 1200 study participants
Last Updated