Summary

Eligibility
for females ages 5-21 (full criteria)
Location
at La Jolla, California and other locations
Dates
study started
estimated completion

Description

Summary

To investigate the safety and tolerability of long-term treatment with oral trofinetide in girls and women with Rett syndrome

Official Title

A 40-Week, Open-label Extension Study of Trofinetide for the Treatment of Girls and Women With Rett Syndrome

Keywords

Rett Syndrome Syndrome Trofinetide

Eligibility

You can join if…

Open to females ages 5-21

  1. Has completed the Week 12/End-of-treatment visit of the antecedent study, Study ACP-2566-003
  2. Met all entry criteria for the antecedent study
  3. May benefit from long-term treatment with open-label trofinetide in the judgment of the Investigator
  4. Can still swallow the study medication provided as a liquid solution or can take it by gastrostomy tube
  5. The subject's caregiver is English-speaking and has sufficient language skills to complete the caregiver assessments
  6. Subject and caregiver(s) must reside in the 48 contiguous states and have been at their present residence for at least 3 months prior to Baseline

You CAN'T join if...

  1. Began treatment with growth hormone during the antecedent study
  2. Began treatment with IGF-1 during the antecedent study
  3. Began treatment with insulin during the antecedent study
  4. Has developed a clinically significant cardiovascular, endocrine (such as hypo- or hyperthyroidism, Type 1 diabetes mellitus, or uncontrolled Type 2 diabetes mellitus), renal, hepatic, respiratory, or gastrointestinal disease (such as celiac disease or inflammatory bowel disease) or has major surgery planned during the study
  5. Subject is judged by the Investigator or the Medical Monitor to be inappropriate for the study due to AEs, medical condition, or noncompliance with investigational product or study procedures in the antecedent study
  6. Has a clinically significant abnormality in vital signs at Baseline
  7. Has a QTcF interval of >450 ms on the Baseline ECG performed before the first dose of trofinetide is given in the present study
  8. Has developed a clinically significant ECG finding during the antecedent study

Additional inclusion/exclusion criteria apply. Patients will be evaluated at baseline to ensure that all criteria for study participation are met. Patients may be excluded from the study based on these assessments (and specifically, if it is determined that their baseline health and condition do not meet all prespecified entry criteria).

Locations

  • University of California, San Diego accepting new patients
    La Jolla California 92093 United States
  • Translational Genomics Research Institute (TGen) accepting new patients
    Phoenix Arizona 85012 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
ACADIA Pharmaceuticals Inc.
ID
NCT04279314
Phase
Phase 3
Study Type
Interventional
Last Updated