for people ages 50 years and up (full criteria)
at La Jolla, California and other locations
study started
estimated completion



The objectives of this study are to evaluate the safety and efficacy of Zimura intravitreal administration in patients with geographic atrophy secondary to age-related macular degeneration (AMD)

Official Title

A Phase 3 Multicenter, Randomized, Double Masked, Sham- Controlled Clinical Trial to Assess the Safety and Efficacy of Intravitreal Administration of Zimura (Complement C5 Inhibitor) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration


Patients will be randomized in a 1:1 ratio to the following monthly treatment groups: - Zimura 2 mg - Sham At month 12, the patients in the Zimura 2mg treatment group will be re-randomized to receive the study drug either on a monthly basis or on an every other month basis The patients initially randomized to Sham treatment will continue with monthly Sham injections through Month 23 All patients will have a final follow up visit at Month 24


Geographic Atrophy Macular Degeneration Geographic Atrophy (GA) Age-related Macular Degeneration AMD Zimura Complement C5 inhibitor avacincaptad pegol Atrophy


You can join if…

Open to people ages 50 years and up

  • Subjects of either gender aged ≥ 50 years
  • Diagnosis of Non-foveal GA secondary to dry AMD

You CAN'T join if...

  • Any prior treatment for AMD (dry or wet) or any prior intravitreal treatment for any indication in either eye, except oral supplements of vitamins and minerals
  • Any intraocular surgery or thermal laser within 3 months of trial entry.
  • Any prior thermal laser in the macular region, regardless of indication
  • Any ocular or periocular infection (including blepharitis), or ocular surface inflammation in the past 12 weeks.
  • Previous therapeutic radiation in the region of the study eye
  • Any sign of diabetic retinopathy in either eye


  • University of California, San Diego
    La Jolla California 92093 United States
  • Gavin Herbert Eye Institute
    Irvine California 92697 United States


in progress, not accepting new patients
Start Date
Completion Date
IVERIC bio, Inc.
Phase 3
Study Type
Last Updated