This study is in progress, not accepting new patients

Study of ATH434 in Participants With Multiple System Atrophy

a study on Multiple System Atrophy

Summary

Eligibility
for people ages 30-75 (full criteria)
Location
at La Jolla, California and other locations
Dates
study started
completion around

Description

Summary

This study will assess the safety and efficacy of ATH434 in participants with Multiple System Atrophy

Official Title

A Randomized, Double-Blind, Placebo-Controlled Study of ATH434 in Multiple System Atrophy

Keywords

Multiple System Atrophy, ATH434, Neurodegenerative disease, Shy-Drager Syndrome, Movement disorders, Autonomic dysfunction, Synucleinopathies, Atypical parkinsonism, Atrophy, ATH434 dose level 1, ATH434 dose level 2

Eligibility

You can join if…

Open to people ages 30-75

  1. Participant has clinical features of parkinsonism.
  2. Participant has evidence of orthostatic hypotension and/or bladder dysfunction.
  3. Participant has ataxia and/or pyramidal signs on neurological examination.
  4. Participant is ambulatory.
  5. Participant has biomarker evidence of MSA in biologic fluid and on MRI.

You CAN'T join if...

  1. Participant has motor symptoms for > 4 years.
  2. Participant has advanced disease, as indicated by frequent falls or choking.
  3. Participant has structural brain abnormality on MRI.
  4. Participant has any significant neurological disorder other than MSA.
  5. Participant has an unstable medical or psychiatric illness.
  6. Participant has a contraindication to, or is unable to tolerate, MRI or lumbar puncture.

Locations

  • University of California San Diego
    La Jolla California 92093 United States
  • The Movement Disorder Clinic of Oklahoma
    Tulsa Oklahoma 74136 United States

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Alterity Therapeutics
ID
NCT05109091
Phase
Phase 2 Multiple System Atrophy Research Study
Study Type
Interventional
Participants
About 77 people participating
Last Updated