Summary

Eligibility
for people ages 18-85 (full criteria)
Location
at La Jolla, California and other locations
Dates
study start
estimated completion

Description

Summary

The primary objective of this study is to compare the effect of treatment with olpasiran, to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants with atherosclerotic cardiovascular disease (ASCVD) and elevated Lipoprotein(a).

Official Title

A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Olpasiran on Major Cardiovascular Events in Participants With Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a)

Keywords

Atherosclerotic Cardiovascular Disease, ASCVD, AMG 890, Olpasiran, Cardiovascular Diseases, Atherosclerosis

Eligibility

You can join if…

Open to people ages 18-85

You CAN'T join if...

  • Severe renal dysfunction
  • Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3 x upper limit of normal (ULN), or total bilirubin (TBL) > 2 x ULN during screening
  • History of hemorrhagic stroke
  • History of major bleeding disorder
  • Planned cardiac surgery or arterial revascularization
  • Severe heart failure
  • Current, recent, or planned lipoprotein apheresis
  • Previously received ribonucleic acid therapy specifically targeting Lp(a)

Locations

  • University of California San Diego accepting new patients
    La Jolla California 92037 United States
  • University of California Irvine accepting new patients
    Orange California 92868 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Amgen
Links
AmgenTrials clinical trials website
ID
NCT05581303
Phase
Phase 3 research study
Study Type
Interventional
Participants
Expecting 6000 study participants
Last Updated