Summary

Eligibility
for people ages 18-65 (full criteria)
Location
at La Jolla, California
Dates
study started
completion around
Principal Investigator
by Beatrice A. Golomb, MD, PhD

Description

Summary

This research study is being conducted to see if coenzyme Q10 (a nutritional supplement) might help to prevent and/or alleviate symptoms and health consequences and help to improve quality of life and physical function in residents affected by the February 2023 East Palestine, Ohio train derailment. This is a pilot study that is not powered to achieve benefit but seek to examine effect size and variance to aid in power calculations for a potential future better powered study.

Keywords

Toxicant Induced Chronic Multisymptom Illness and Associated Symptoms and Comorbidities, Mixed toxic chemicals, Chronic multisymptom illness, Train derailment, Ubiquinone, Coenzyme Q10, Ubiquinone 100 mg Oral Soft Gel

Eligibility

You can join if…

Open to people ages 18-65

  • On Feb. 3, 2023, lived within 10 miles of the East Palestine, OH train derailment (closer in will receive preference). Others who were in the area for toxin mitigation and other reasons and show compatible symptoms will also be eligible.
  • Meets Kansas symptom criteria for multi-symptom illness - originally defined for Gulf War Illness (has persistent symptoms, lasting greater than six months, that are of >mild severity in at least three of the six domains of fatigue/sleep, pain, neurological/cognitive/mood, gastrointestinal, respiratory and dermatologic). At least some symptoms must be new or worsened since the derailment.
  • Access to internet and smart phone or computer for remote Qualtrics survey participation.
  • Willing to perform the stipulated study elements.
  • Took ≥80% of run-in soft gels.

You CAN'T join if...

  • Anticipated move from the area or other anticipated obstacle to participating for study duration.
  • Participating in another clinical trial.
  • Has a pre-existing health condition expected to produce significant and variable fluctuating symptoms (e.g. chronic infection and/or active cancer other than non-melanoma skin cancer).
  • Contraindications to CoQ10, such as use of coumadin (although an interaction with CoQ10 is controversial).

Location

  • UC San Diego
    La Jolla California 92093 United States

Lead Scientist at UCSD

  • Beatrice A. Golomb, MD, PhD
    Professor In Residence, Medicine, Vc-health Sciences-schools. Authored (or co-authored) 103 research publications

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Diego
ID
NCT06962657
Phase
Phase 2
Study Type
Interventional
Participants
Expecting 20 study participants
Last Updated