Cystic Fibrosis clinical trials at UCSD
8 in progress, 1 open to eligible people
Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
open to eligible people ages 6 years and up
The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms in people with CF that needs medical intervention. Both doctors and CF patients are trying to understand the best way to treat pulmonary exacerbations. This study is trying to answer the following questions about treating a pulmonary exacerbation: - Do participants have the same improvement in lung function and symptoms if they are treated with one type of antibiotic (called beta-lactams or β-lactams) versus taking two different types of antibiotics (tobramycin and β-lactams)? - Is taking one type of antibiotic just as good as taking two types?
La Jolla, California and other locations
RCT2100 in Healthy Participants and in Participants With CF
Sorry, not currently recruiting here
This is the first-in-human study with RCT2100 and is designed to provide safety and tolerability data for future clinical studies.
San Diego, California and other locations
Streamlined Treatment of Pulmonary Exacerbations in Pediatrics
Sorry, not currently recruiting here
The STOP PEDS RCT is a multicenter, parallel, open label randomized controlled trial evaluating the long-term (one year) and short-term safety and efficacy of two antibiotic treatment strategies for the management of outpatient pulmonary exacerbations (PEx) in the pediatric CF population.
San Diego, California and other locations
Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators
Sorry, not currently recruiting here
The REACH study is for people with CF who do not take cystic fibrosis transmembrane conductance regulator (CFTR) modulators. The goal of the REACH study is to collect research data, including health data and specimens, from people with CF who do not take CFTR modulators. This data may be used to inform CF research, help design CF clinical trials and support the development of new treatments for people with CF who do not take CFTR modulators. Another goal of this study is to learn about research involvement for people with CF who do not take CFTR modulators, engage them in research, and give them an opportunity to learn about what is involved in participating in a CF research study.
La Jolla, California and other locations
CHaractErizing CFTR Modulated Changes in Sweat Chloride and Their Association With Clinical Outcomes
Sorry, in progress, not accepting new patients
This is a multicenter, cross-sectional, cohort study which will collect contemporary sweat chloride (SC) values from approximately 5000 Cystic Fibrosis (CF) patients prescribed and currently receiving commercially approved Cystic Fibrosis transmembrane conductance regulator (CFTR) modulator therapies.
La Jolla, California and other locations
PATIENCE Trial: Prospective Algorithm for Treatment of NTM in Cystic Fibrosis
Sorry, accepting new patients by invitation only
Isolation of nontuberculous mycobacteria (NTM) from the sputum of individuals with CF is an increasingly common finding, and the lack of an evidenced-based approach to treatment of NTM disease has been identified as one of the greatest unmet needs within the CF community. Current evidence predicts that the prevalence of NTM will remain relatively high in the CF population. Approaches to NTM disease treatment differ widely between centers, and expected outcomes are not known. This study is observational and follows current best practices. The study will help define response to treatment, and collect relevant data associated with treatment of NTM disease to build a framework for future therapeutic trials.
San Diego, California and other locations
PREDICT Trial: PRospective Evaluation of NTM Disease In CysTic Fibrosis
Sorry, accepting new patients by invitation only
Isolation of nontuberculous mycobacteria (NTM) from the sputum of individuals with CF is an increasingly common finding, and the lack of an evidenced-based approach to the diagnosis of NTM disease has been identified as one of the greatest unmet needs within the CF community. Current evidence predicts that the prevalence of NTM will remain relatively high in the CF population. Approaches to NTM disease diagnosis differ widely between centers. This study is observational and follows current best practices. The study will help standardize the diagnosis and collect relevant data associated with the diagnosis of NTM disease to build a framework for future therapeutic trials.
San Diego, California and other locations
Pregnancy in Women with Cystic Fibrosis
Sorry, in progress, not accepting new patients
In this study, the investigators aim to evaluate changes in lung function in women with cystic fibrosis (CF) during pregnancy and for 2 years after pregnancy based on exposure to highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators.
La Jolla, California and other locations
Our lead scientists for Cystic Fibrosis research studies include Kathryn Akong, MD.
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