for females ages 16 years and up (full criteria)
at La Jolla, California and other locations
study started
completion around



In this study, the investigators aim to evaluate changes in lung function in women with cystic fibrosis (CF) during pregnancy and for 2 years after pregnancy based on exposure to highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators.

Official Title

A Prospective Study Evaluating Maternal and Fetal Outcomes in the Era of Modulators


Advances in medical treatment, including the use of highly effective CFTR modulators have greatly increased life expectancy in women with CF, but the effects of pregnancy on women with CF are yet unknown. It is anticipated that over 90% of the CF population will be on CFTR modulators in the next few years. More knowledge about the effects of CFTR modulators in pregnancy is needed.

This is a prospective, multi-center, observational study to follow pregnant women with CF, conducted at 40 US sites. Women are enrolled in the first trimester of pregnancy and assessed every 3 months during pregnancy and during the first year after delivery, then every 6 months for an additional year. Changes in lung function over the course of pregnancy will be evaluated based on cumulative CFTR modulator use while pregnant while accounting for other factors that may influence changes in pulmonary function: baseline lung function, genotype, history of exacerbations, and pre-existing co-morbid conditions.


Pregnancy Related, Cystic Fibrosis, Pregnancy/obstetric health in women with cystic fibrosis, Pregnancy, CFTR modulators, Fibrosis


You can join if…

Open to females ages 16 years and up

- Pregnant, intending to continue pregnancy, enrolled in the Cystic Fibrosis Foundation Patient Registry (CFFPR)

You CAN'T join if...

- None


  • University of California San Diego accepting new patients
    La Jolla California 92093 United States
  • Center for Cystic Fibrosis at Keck Medical Center of USC accepting new patients
    Los Angeles California 90033 United States


accepting new patients
Start Date
Completion Date
Amalia Magaret
Study Type
Expecting 285 study participants
Last Updated