Heart Conditions clinical trials at UCSD

6 in progress, 3 open to eligible people

Showing trials for

  • iCLAS™ for Persistent Atrial Fibrillation

    open to eligible people ages 18-80

    Clinical study to evaluate the safety and efficacy of the Adagio AF Cryoablation System (iCLAS™) in the ablation treatment of symptomatic, persistent atrial fibrillation (PsAF). Data will be used to support a pre-market application (PMA)

    San Diego, California and other locations

  • Substrate Versus Trigger Ablation for Paroxysmal Atrial Fibrillation

    open to eligible people ages 21 years and up

    This is a prospective randomized study to assess the safety and efficacy of FIRM (Focal Impulse and Rotor Modulation)-guided ablation for the treatment of symptomatic atrial fibrillation (AF). The study hypothesis is that the efficacy of AF elimination at 1 year will be higher by ablating patient-specific AF-sustaining rotors and focal sources by Focal Impulse and Rotor Modulation (FIRM) compared to conventional ablation alone (wide-area PV isolation).

    San Diego, California and other locations

  • Comprehensive Computed Tomography Guidance of Coronary Bypass Graft Surgery

    open to eligible people ages 40 years and up

    Apply CT angiography, CT perfusion imaging and advanced image processing techniques to improve revascularization decision-making and surgical strategies in patients undergoing coronary artery bypass graft surgery.

    San Diego, California and other locations

  • aMAZE Study: LAA Ligation Adjunctive to PVI for Persistent or Longstanding Persistent Atrial Fibrillation

    Sorry, in progress, not accepting new patients

    This study is a prospective, multicenter, randomized (2:1) controlled study to evaluate the safety and effectiveness of the LARIAT System to percutaneously isolate and ligate the Left Atrial Appendage from the left atrium as an adjunct to planned pulmonary vein isolation (PVI) catheter ablation in the treatment of subjects with symptomatic persistent or longstanding persistent atrial fibrillation. This study will be conducted in two stages: - Limited Early Stage (Stage 1): up to 250 subjects at up to 65 sites. (COMPLETED, transitioned to Stage 2) - Pivotal Stage/ Phase III (Stage 2): up to 600 subjects at up to 65 sites. (COMPLETED) All subjects from both stages will be included in the primary analysis.

    La Jolla, California and other locations

  • Evaluation of Conventional Ablation With or Without Focal Impulse and Rotor Modulation to Eliminate Human AF

    Sorry, not currently recruiting here

    This prospective randomized study will assess the safety and efficacy of FIRM-guided ablation (FIRM+PVI) compared to pulmonary vein isolation (PVI) without FIRM, for the treatment of symptomatic atrial fibrillation.

    San Diego, California and other locations

  • TactiFlex AF IDE Trial

    Sorry, in progress, not accepting new patients

    Prospective non-randomized parallel-assignment multi-center clinical investigation. The study design includes two subject cohorts: 1) PAF Main Study, and 2) PAF High Standard Power (HSP) Substudy. Subjects in the main study cohorts are to be treated using the full range of ablation power settings in the IFU. Subjects in the HSP Substudy are to be treated in the upper end of the recommended ablation power settings (40-50 Watts).

    San Diego, California and other locations

Our lead scientists for Heart Conditions research studies include .

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