for people ages 40 years and up (full criteria)
at San Diego, California and other locations
study started
completion around
Principal Investigator
by Andrew Kahn, MD



Apply CT angiography, CT perfusion imaging and advanced image processing techniques to improve revascularization decision-making and surgical strategies in patients undergoing coronary artery bypass graft surgery.

Official Title

Comprehensive CT Guided Coronary Bypass Graft Surgery


The objective of this study is to integrate noninvasively acquired anatomical and functional information to develop clinically applicable tools for meaningful per-vessel revascularization decisions. The decisions will be based on quantitative lesion-specific ischemia and viability and flow simulations. These will be based on CT anatomy enhanced with a function for prediction of hemodynamic improvement after CABG.

Aim 1: Predict restoration of myocardial perfusion from coronary artery bypass graft surgery. The investigators will perform cardiac CT before and after CABG and measure absolute changes in myocardial perfusion as the functional outcome of CABG. The investigators will investigate clinical, surgical and imaging variables in association with post-CABG perfusion improvement on a per-vessel and per-patient level.

Aim 2: Non-invasively quantify vessel-specific ischemia for meaningful CABG decisions.

The investigators will develop and validate tools for assessment of vessel-specific ischemia and viability. The investigators will assess the potential impact of CT guided CABG by comparing the per-vessel need for grafting with standard care.

Aim 3: Predict CABG benefit through multi-parameter flow simulations Hypothesis: Integration of myocardial perfusion and viability can improve flow simulation models to predict CABG outcome. The investigators will develop new computational fluid dynamics models enriched with functional parameters and explore the potential of virtual grafting to improve hemodynamic outcomes.


CAD, Atheroscleroses, Coronary, Computed Tomography, Coronary Artery Bypass, Atherosclerosis, Coronary Artery Disease, Myocardial Ischemia


You can join if…

Open to people ages 40 years and up

  • Planned elective CABG for coronary artery disease.
  • CABG is the primary indication for surgery (but may include treatment of mild-moderate valvular disease).
  • Age: ≥40 years.

You CAN'T join if...

  • Technical feasibility of the cardiac CT exams: redo-CABG, significant arrhythmia/mal-conduction, congenital conditions, severe valvular disease or cardiomyopathy (to the extent that the CT acquisition is technically challenged), inadequate understanding of the English language (to provide consent or follow instructions during the exams).
  • Overall safety: unstable clinical condition (clinical heart failure, unstable angina, myocardial infarction <1 month prior).
  • Radiation risk: pregnancy (cannot be ruled out), body weight >100kg.
  • CT contrast medium-related: known allergy, renal failure
  • Vasodilator related: known allergy, bronchial asthma requiring daily use of bronchodilators, Mobitz II or 3rd degree AV block, sick sinus node disease, clinically significant carotid artery narrowing, severe aortic stenosis or LVOT narrowing, systolic blood pressure below 90mmHg, (continued) use of dipyridamole or aminophylline.
  • Inability to provide informed consent.


  • University of California San Diego accepting new patients
    San Diego California 92093 United States
  • Palo Alto Veterans Affaird Healthcare System accepting new patients
    Palo Alto California 94304 United States
  • Stanford University accepting new patients
    Palo Alto California 94304 United States

Lead Scientist at UCSD

  • Andrew Kahn, MD
    Clinical Professor, Medicine, Vc-health Sciences-schools. Authored (or co-authored) 63 research publications


accepting new patients
Start Date
Completion Date
Stanford University
Study Type
Expecting 200 study participants
Last Updated