for people ages 18-80 (full criteria)
at San Diego, California and other locations
study started
estimated completion
Robert L. Owens



The goal of this study is to determine if sleep disordered breathing results in a measurable degree of overnight myocardial stress/injury in patients with acutely decompensated congestive heart failure. A secondary goal is to determine of a period of medical management attenuates this sleep disordered breathing-induced cardiac injury in this patient population.

Official Title

Impact of Sleep Disordered Breathing on Cardiac Injury in Acutely Decompensated Congestive Heart Failure


Consecutive patients admitted to the hospital with acutely decompensated heart failure will be identified for potential enrollment in this study. Enrolled patients will first be asked to complete questionnaires to assess their symptoms and risk of having sleep apnea.

Relevant information will be obtained from the electronic medical record (age, gender, body mass index, co-morbidities, medications, prior echocardiography results). Subjects will then undergo a "type III" portable monitoring sleep study on the first or second night of their hospital admission, which measures respiratory effort, nasal airflow, oxyhemoglobin saturation, and heart rate. Blood samples will be collected on the evening before (08:00 PM +/- 2 hours), and the morning after (06:00 AM +/-2 hours) sleep apnea testing. If not otherwise obtained clinically, echocardiography will be obtained within 48 hours of admission. After a period of medical management for acutely decompensated heart failure, subjects will then have a second portable sleep apnea study (with associated pre and post-sleep blood draws) on the evening prior to discharge (approximately hospital day 5 or 6). Later, clinical outcomes such as incidence of renal dysfunction, hospital length of stay etc. will be collected from the electronic medical record. Blood samples will be processed, stored, and subsequently analyzed for high-sensitivity cardiac troponin T and I.


Obstructive Sleep ApneaHeart Failure; With DecompensationSleepOSACSACHFHeart FailureTroponinSleep Apnea, ObstructiveSleep Apnea Syndromes


You can join if…

Open to people ages 18-80

  • Patients age 18-80 years admitted to University of California San Diego La Jolla campus (Sulpizio Cardiovascular Center, Jacobs Medical Center, and Thornton Hospital) with acute decompensated heart failure will be identified in the emergency department, or upon admission to the cardiology or inpatient general medical services.

You CAN'T join if...

  • Known diagnosis of sleep disordered breathing and on treatment while hospitalized.
  • Suspected acute coronary syndrome as determined by the primary clinical team.
  • Intensive care unit level care.
  • Requiring advanced heart failure therapy such as inotrope infusion, mechanical circulatory support etc.
  • Intolerance of study procedures.
  • Clinical attending physician refusal


  • University of California San Diego
    San DiegoCalifornia92121United States
  • Altman Clinical and Translational Research Institute
    San DiegoCalifornia92093-0990United States

Lead Scientist


not yet accepting patients
Start Date
Completion Date
University of California, San Diego
Study Type
Last Updated