for people ages 17-90 (full criteria)
at San Diego, California
study started
estimated completion
Principal Investigator
by Krishnan Chakravarthy, MD/PhD
Photo of Krishnan Chakravarthy
Krishnan Chakravarthy



This study will assess the feasibility of developing the Neurofeedback-EEG-VR (NEVR) system for non-opioid pain therapy. Subjects suffering from pain will undergo sessions involving VR and Neurofeedback training and their pain will be assessed.

Official Title

Neurofeedback-EEG-VR (NEVR) System for Non-opioid Pain Therapy


QUASAR and UCSD are conducting a clinical trial on 25 subjects to evaluate the feasibility of a novel Neurofeedback electroencephalography (EEG) Virtual Reality (VR) system aimed at reducing chronic pain. The NEVR device consists of a dry electrode EEG headset combined with a VR Head-Mounted Display (VR-HMD) device and neurofeedback software. This approach relies on retraining the brain's networks to reduce the perception of pain and does not involve pharmaceutical drugs. Patients with chronic lower back pain will be recruited by UCSD at its Altman Clinical & Translational Research Institute. Patients that meet the recruitment criteria will be asked to conduct 20 1-hour long sessions of EEG-based Neurofeedback in VR over the course of a couple of months. Pain assessment and device usability questionnaires will be conducted prior to and after the first and last sessions, and at intermediate time points. This will be a single arm clinical trial aimed at demonstrating the safety and viability of the NEVR device, with the primary outcome measure being the ability of patients to conduct all 20 sessions safely and comfortably. Secondary outcome measures include assessment of changes in pain perception, and of changes in EEG activity patterns.


Pain Management NEVR


You can join if…

Open to people ages 17-90

  • Chronic back pain that can be of multifactorial etiology inclusive of axial and radicular back pain
  • Report a Numerical Rating Scale (NRS, or Visual Analog Score VAS) score of greater than 6/10
  • Must be willing to for the duration of the study make no pharmacological adjustments or have additional Interventional therapies, as reported by the patient
  • Must have the cognitive capacity to provide consent/assent
  • Must be able to sit up in a chair during the recording session
  • Must demonstrate understanding of the protocol, its purpose and subject participation
  • Must be fluent in English

You CAN'T join if...

  • Measured head size too small or too large for the EEG equipment
  • Any significant skull defect
  • History of a recent craniotomy (within the last six months)
  • Any signs of scalp inflammation, irritation, or abnormal skin conditions
  • History of epilepsy or seizures
  • Known allergies to any material to be used in this project
  • Sight disabilities that make participation impractical
  • Hair styles with thick braids or dread locks


  • Altman Clinical and Translational Research Institute accepting new patients
    San Diego California 92037 United States

Lead Scientist at UCSD


accepting new patients
Start Date
Completion Date
Quantum Applied Science & Research, Inc.
Lead organization website Subaward research site
Study Type
Last Updated