Summary

Eligibility
for people ages 18-50 (full criteria)
Dates
study started
estimated completion
Principal Investigator
by Jyoti Mishra, PhD
Photo of Jyoti Mishra
Jyoti Mishra

Description

Summary

Repetitive Transcranial magnetic stimulation (rTMS) is an FDA-approved treatment for depression that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. The ultimate goal of this treatment is to increase excitability and long-term plasticity in DLPFC, a brain region shown to be hypo-active in depression. Unfortunately, rTMS only has low to moderate efficacy; remission rates for patients ranges from ~15-30% in large randomized controlled trials. The focus of this research is to develop a next-generation rTMS protocol that is guided by the basic principles underlying brain plasticity, in order to improve the efficacy of rTMS for the treatment of depression. Specifically, in this study the investigators will test rTMS paired with depression-relevant cognitive states (Cog-TMS).

Official Title

Personalized Closed-Loop Brain Stimulation for Depression

Details

Repetitive Transcranial magnetic stimulation (rTMS) is an FDA-approved treatment for depression that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. The ultimate goal of this treatment is to increase excitability and long-term plasticity in DLPFC, a brain region shown to be hypo-active in depression. Unfortunately, rTMS only has low to moderate efficacy; remission rates for patients ranges from ~15-30% in large randomized controlled trials. The focus of this research is to develop a next-generation rTMS protocol that is guided by the basic principles underlying brain plasticity, in order to improve the efficacy of rTMS for the treatment of depression. Specifically, in this study the investigators will test rTMS paired with depression-relevant cognitive states (Cog-TMS) during an attention-to-breath task. In this task, the investigators have shown that DLPFC theta activity during the task is associated with increased mindfulness; the protocol will pair the task with the intermittent Theta Burst Stimulation (iTBS) protocol of ~5 minutes duration.

Keywords

Depression Depressive Disorder CogTMS

Eligibility

You can join if…

Open to people ages 18-50

• moderate-severe depression (PHQ-9 scale score >9 with confirmation using Structured Clinical Interview for DSM Disorders (SCID-I))

You CAN'T join if...

  • active substance abuse/dependence
  • psychotic disorders
  • any factor that increases risk of TMS (metal implants/history of stroke/seizure disorder).
  • displaying acutely suicidal behaviors on the Columbia Suicide Severity Rating Scale.

Lead Scientist at UCSD

  • Jyoti Mishra, PhD
    Dr. Mishra is trained in the computational, cognitive and translational neurosciences. She is the founder of the Neural Engineering & Translation Labs (NEATLabs) at UCSD. Her lab innovates digital technologies for scalable brain health mapping, monitoring and precision therapeutics.

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Diego
ID
NCT04586699
Study Type
Interventional
Last Updated