for people ages 21-74 (full criteria)
Healthy Volunteers
healthy people welcome
at San Diego, California
study started
estimated completion
Principal Investigator
by Cheryl A. Anderson, PhD
Headshot of Cheryl A. Anderson
Cheryl A. Anderson



In this research study, the investigators will use a novel approach to measure what people eat. The goal is to find out whether stable isotopes that can be measured in blood, hair, and fingernails are better at measuring what people eat than the surveys that are currently used. To meet the goal, the investigators will do three things. First, the investigators will feed study participants known amounts of foods and nutrients. Second, after study participants have eaten the food, the investigators will measure stable isotopes in samples of study participants' blood, hair, and fingernails. Third, the investigators will determine how well these samples reflect what was eaten. The investigators will also give surveys to study participants to determine how well the surveys reflect what was eaten. This will allow the investigators to do a relative comparison of the measurements from isotopes and surveys.


This is a controlled feeding study in which the relative validity of stable carbon and nitrogen isotope ratio analysis as a biomarker of dietary intake is compared to controlled feedings and multiple 24-hour recalls. Participants will be randomly assigned to a sequence of diets to be fed on four occasions. Participants will undergo 24 hours of controlled feeding on four non-consecutive days over a month-long period. On the day after feeding, participants will complete 24-hour dietary recalls, and provide blood, hair, and fingernail samples for isotope ratio analyses. The investigators will use a crossover design and the diets will be either high or low in C4 plants (i.e., corn and cane products). A 24-hour urine collection will be done at home during each 24-hour feeding period. Participants will have height and weight measured at the screening visit. Weight will also be measured at each study visit. Additionally, data will be collected via questionnaires administered at each study visit.


Healthy Adults, Isotopes, Sugar, Diet, Health, Cardiovascular Diseases, one 24 hr cycle of meals at a 2000 kcal level, one 24 hr cycle of meals at a 2000 kcal level + one serving sugar sweetened beverage, one 24 hr cycle of meals at a 2000 kcal level + two servings sugar sweetened beverage, one 24 hr cycle of meals at a 2000 kcal level + three serving sugar sweetened beverage


You can join if…

Open to people ages 21-74

  • men and women;
  • aged 21 and 74 years;
  • no history of chronic disease and in general good health;
  • able to provide primary study outcome; and
  • willing to tolerate study diets designed for controlled feeding.

You CAN'T join if...

  • recent dietary changes, restrictions, allergies or preferences;
  • health conditions that require management beyond the scope of the study (e.g. heart failure, kidney disease, liver disease, gastrointestinal disorder);
  • history of drug or alcohol abuse;
  • plans to leave the San Diego area before study completion; and
  • lack of suitability per investigators' discretion.


  • University of California, San Diego
    San Diego California 92093 United States

Lead Scientist at UCSD

  • Cheryl A. Anderson, PhD
    Cheryl A. M. Anderson is a Professor and Dean of the University of California San Diego Herbert Wertheim School of Public Health and Human Longevity Science. Dr. Anderson's research focuses on nutrition and chronic disease prevention in underserved populations using observational epidemiologic study designs, randomized clinical trials, and implementation science.


not yet accepting patients
Start Date
Completion Date
University of California, San Diego
Study Type
Expecting 10 study participants
Last Updated