Summary

Eligibility
for males ages 18 years and up (full criteria)
Location
at La Jolla, California and other locations
Dates
study started
completion around

Description

Summary

This research is being done to see if we can improve the outcome of prostate cancer patients who present with metastatic lesions at initial diagnosis.

Official Title

Phase 2 Randomized Total Eradication of Metastatic Lesions Following Definitive Radiation to the Prostate in De Novo OligometaStatic Prostate Cancer (TERPS) Trial

Details

This study will compare the effects, good and/or bad, of using the standard of care treatment (systemic therapy + primary prostate radiation) compared to standard of care treatment plus stereotactic ablative radiation therapy (SABR) to metastatic lesions for prostate patients. The researchers are also trying to learn if the addition of SABR will affect recurrence rates. Presence of circulating tumor cells, gut bacteria, and quality of life will be assessed for both groups.

Keywords

Prostate Cancer, Oligometastatic Disease, Prostatic Neoplasms, Prostate radiation (XRT), Systemic Therapy, Stereotactic ablative radiation therapy (SABR), BST + XRT + SABR metastasis-directed therapy (MDT)

Eligibility

You can join if…

Open to males ages 18 years and up

  1. Patient must have at least one and up to three asymptomatic metastatic tumor(s) of the bone or soft tissue (with at least one bone metastasis) develop within the past 6-months that are seen on imaging. Up to five lesions are allowed on advanced functional imaging such as fluciclovine (Axumin), choline or PSMA PET-CT scan.
    1. CT or MRI scan within 6 months of enrollment
    2. Bone scan within 6 months of enrollment
    3. Fluciclovine (Axumin), choline, or PSMA PET-CT scan within 6 months of enrollment (PET-CT scan is reasonable for study entry imaging as an alternative to CT/MRI scan and bone scan)
  2. Histologic confirmation of malignancy (primary or metastatic tumor).
  3. Patient may have had prior systemic therapy and/or ADT associated with treatment within 9-months of enrollment.
  4. PSA > 0.5 but <100.
  5. Patient must be ≥ 18 years of age.
  6. Patient must have a life expectancy ≥ 12 months.
  7. Patient must have an ECOG performance status ≤ 2.
  8. Patient must have the ability to understand and the willingness to sign a written informed consent document

You CAN'T join if...

  1. Castration-resistant prostate cancer (CRPC).
  2. Prior radiation therapy to an overlapping site of a target lesion that would preclude further radiation therapy
  3. Spinal cord compression or impending spinal cord compression.
  4. Suspected pulmonary and/or liver metastases (greater >10 mm in largest axis).
  5. Patient receiving any other investigational agents.
  6. Inability to receive any form of systemic therapy in the opinion of a treating medical oncologist .
  7. Unable to lie flat during or tolerate PET/MRI, PET/CT or SABR.
  8. No radiographical evidence of cranial metastasis.
  9. Refusal to sign informed consent.

Locations

  • UC San Diego Moores Cancer Center accepting new patients
    La Jolla California 92093 United States
  • UPMC Hillman Cancer Center accepting new patients
    Pittsburgh Pennsylvania 15232 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of Maryland, Baltimore
ID
NCT05223803
Phase
Phase 2 research study
Study Type
Interventional
Participants
Expecting 122 study participants
Last Updated