Summary

Eligibility
for people ages 12 years and up (full criteria)
Location
at La Jolla, California and other locations
Dates
study started
completion around
Principal Investigator
by Chelsey J F Smith
Headshot of Chelsey J F Smith
Chelsey J F Smith

Description

Summary

The trial will evaluate efficacy, safety and tolerability of two regimens of ianalumab compared to placebo, given as monthly or quarterly subcutaneous (s.c.) injection on top of standard-of-care (SoC) treatment in participants with active systemic lupus erythematosus (SLE).

Official Title

A Randomized, Double-blind, Parallel Group, Placebo-controlled Multicenter Phase 3 Study to Evaluate Efficacy, Safety and Tolerability of Two Regimens of Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 1)

Details

A randomized, double-blind, parallel group, placebo-controlled multicenter phase 3 study to evaluate efficacy, safety and tolerability of two regimens of ianalumab on top of standard-of-care therapy in patients with systemic lupus erythematosus (SIRIUS-SLE 1)

Keywords

Systemic Lupus Erythematosus, SLE, B cell depletion, SLEDAI-2K, BILAG-2004, SRI, ANA, Ianalumab, Ianalumab s.c. monthly, Ianalumab s.c. quarterly

Eligibility

You can join if…

Open to people ages 12 years and up

  • Male and female participants aged 12 years or older at the time of screening, or limited to 18 years or older in European Economic Area countries and other countries where inclusion of participants below 18 years is not allowed.
  • Diagnosis of systemic lupus erythematosus meeting the 2019 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) SLE classification criteria at least 6 months prior to screening.
  • Elevated serum titers at screening of anti-nuclear antibodies ≥ 1:80 as determined by a central laboratory with a SLE-typical fluorescence pattern.
  • Currently receiving CS and/or anti-malarial treatment and/or another disease-modifying antirheumatic drug (DMARD) as specified in the protocol.
  • SLEDAI-2K criteria at screening: SLEDAI-2K score ≥ 6 points, excluding points attributed to "fever", "lupus headache", "alopecia", and "organic brain syndrome"
  • BILAG-2004 disease activity level at screening of at least 1 of the following:
    • BILAG-2004 level 'A' disease in ≥ 1 organ system, Or
    • BILAG-2004 level 'B' disease in ≥ 2 organ systems
  • Weigh at least 35 kg at screening

You CAN'T join if...

  • Prior treatment with ianalumab
  • History of receiving following treatment: I) high dose CS, calcineurin inhibitors, JAK or other kinase inhibitors or other DMARD (except as listed in inclusion criteria) administered within 12 weeks prior to screening. II) cyclophosphamide or biologics such as immunoglobulins (intravenous or s.c.), plasmapheresis, anti-type I interferon receptor biologic agents, anti-CD40 agents, CTLA4-Fc Ig or B-cell activating factor (BAFF)-targeting agents administered within 24 weeks prior to screening; belimumab administered within 12 weeks prior to screening. III) any B cell-depleting therapies, other than ianalumab administered within 36 weeks prior to randomization or as long as B cell count is less than the lower limit of normal or baseline value prior to receipt of B cell-depleting therapy (whichever is lower). IV) Traditional Chinese medicines administered within 30 days prior to randomization.
  • Active viral, bacterial or other infections requiring intravenous or intramuscular treatment for clinically significant infection
  • Chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV)
  • Evidence of active tuberculosis infection
  • History of primary or secondary immunodeficiency, including a positive human immunodeficiency virus (HIV) test result at screening
  • Any one of the following abnormal laboratory values prior to randomization
    • Platelets < 25000/mm3 (< 25 x 103/μL)
    • Hemoglobin (Hgb) < 8.0 g/dL (< 5 mmol/L), or < 7.0 g/dL (< 4.3 mmol/L) if related to participant's SLE such as in active hemolytic anaemia
    • Absolute neutrophil count (ANC) (< 0.8 x 103/ μL)
  • Severe organ dysfunction or life-threatening disease at screening
  • Presence of severe lupus kidney disease as defined by proteinuria above 2 g/day or equivalent using spot urine protein creatinine ratio, or serum creatinine greater than 2.0 mg/dL (176.84 µmol/L), or requiring immune-suppressive induction or maintenance treatment at screening
  • Receipt of live/attenuated vaccine within a 4-week period before first dosing
  • Any uncontrolled, co-existing serious disease, which in the opinion of the investigator will place the participant at risk for participation or interfere with evaluation for SLE-related symptoms
  • Non-lupus conditions such as asthma, gout or urticaria, requiring intermittent or chronic treatment with systemic CS
  • History of malignancy of any organ system other than localized basal cell carcinoma of the skin or in situ cervical cancer
  • Pregnant or nursing (lactating) women.
  • Women of child-bearing potential (WOCBP), defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception while on study treatment and for 6 months after stopping of investigational drug.
  • Any surgical, medical, psychiatric or additional physical condition that may jeopardize participation in this study

Locations

  • University of California San Diego . accepting new patients
    La Jolla California 92093 United States
  • Keck School of Medicine Keck Medicine of USC accepting new patients
    Los Angeles California 90033 United States

Lead Scientist at UCSD

  • Chelsey J F Smith
    Assistant Clinical Professor, Medicine, Vc-health Sciences-schools. Authored (or co-authored) 6 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Novartis Pharmaceuticals
ID
NCT05639114
Phase
Phase 3 Lupus Research Study
Study Type
Interventional
Participants
Expecting 406 study participants
Last Updated