for people ages 18-65 (full criteria)
at La Jolla, California
study started
completion around
Principal Investigator
by Eric Granholm, PhD
Headshot of Eric Granholm
Eric Granholm



This open trial will test a new technology-supported blended intervention, mobile Social Interaction Therapy by Exposure (mSITE), that targets social engagement in consumers with serious mental illness.


Social isolation is common in serious mental illness and has a profound negative impact on recovery. This study evaluates a new technology-supported blended intervention, mobile Social Interaction Therapy by Exposure (mSITE), that targets social behavior, and it also validates several new techniques for measuring social behavior. mSITE blends brief in-person psychotherapy with context-triggered mobile smartphone intervention and remote telephone coaching. The investigators will conduct an open trial of mSITE, evaluating whether the intervention leads to clinically significant changes in the frequency of social interactions. The investigators will also determine the dose of app plus remote coaching necessary to achieve this effect, by evaluating change at 12, 18, or 24 weeks. If found to be effective, a scalable intervention that reduces social isolation in serious mental illness would have significant personal, societal, and economic impact.


Schizophrenia, Schizoaffective Disorder, Mood Disorder, Psychotic, Mental Disorders, Psychotic Disorders, Mood Disorders, Psychotic Affective Disorders, mobile Social Interaction Therapy by Exposure (mSITE)


You can join if…

Open to people ages 18-65

  1. Voluntary informed consent to participate and capacity to consent;
  2. Age 18 to 65;
  3. DSM-5 diagnosis of schizophrenia, schizoaffective, bipolar I disorder or major depression with history of psychosis based on a SCID-5 interview and available medical record review;
  4. Minimum level of social avoidance defined by a score of ≥ 2 on the Scale for the Assessment of Negative Symptoms (SANS) asociality item;
  5. ≥ 6th grade reading level on the Wide Range Achievement Test-4 Reading subtest (to read therapy workbook).

You CAN'T join if...

  1. Prior CBT in the past 2 years;
  2. Greater than moderate disorganization on the PANSS (P2- Disorganization item >5);
  3. DSM-5 alcohol or substance dependence in past 3 months based on the SCID;
  4. Level of care required interferes with outpatient therapy (e.g., hospitalized; severe medical illness)
  5. Unable to adequately see or manually manipulate a phone;
  6. Resident of an integrated housing facility that also provides treatment services.


  • UC San Diego
    La Jolla California 92093 United States

Lead Scientist at UCSD

  • Eric Granholm, PhD
    Dr. Granholm is Professor, Vice Chair for Clinical Research, and Director of the Center for Mental Health Technology in the Department of Psychiatry at UC San Diego. He received his Ph.D. in Clinical Psychology from the University of California, Los Angeles in 1991, and completed a postdoctoral fellowship at the UCLA Semel Institute for Neuroscience and Human Behavior.


in progress, not accepting new patients
Start Date
Completion Date
University of California, San Diego
Study Type
About 46 people participating
Last Updated