for people ages 18 years and up (full criteria)
at San Diego, California
study started
completion around
Principal Investigator
by Yash B. Joshi, MD PhD



Veterans with mental illness face challenges with community reintegration, including achieving vocational success, attaining their educational goals and going back to school, and maintaining a high quality of life. VA Mental Health Residential Rehabilitation Treatment Programs, Psychosocial Rehabilitation and Recovery Centers and other mental health treatment programs are designed to help Veterans overcome these barriers, but cognitive impairment often seen in Veterans with mental illness limits gains from these settings. Cognitive remediation interventions can be helpful, but they are either "one-size fits all," and thus may not be useful for all Veterans with mental illness, or are too narrow in scope, focusing on specific mental illnesses, limiting generalizability.

This project will test whether an objective neurophysiological biomarker, mismatch negativity (MMN), can better match the "right" Veteran to the "right" cognitive remediation treatment regardless of their specific mental health diagnosis.

Official Title

Optimizing Cognitive Remediation in VA Mental Health Rehabilitation Settings


This is an observational, non-interventional study. Veterans with mental health diagnoses currently engaged in, or within 6 weeks of discharge from VA Mental Health Residential Rehabilitation Treatment Programs (RRTP), Psychosocial Rehabilitation and Recovery Centers (PRRC), and other mental health treatment settings (inpatient or outpatient mental healthcare) will be recruited. Veterans will have their cognitive functioning assessed. Following this, mismatch negativity (MMN) will be assessed via electroencephalography (EEG). Participants will undergo a 1 hour computerized cognitive training program. They will be interviewed about their attitudes about EEG and computerized cognitive training. They will be followed monthly for a total of 4 months from study entry to assess recovery trajectory. This study aims to enroll 104 Veterans from the VA San Diego Healthcare System.

The Specific Aims of this proposal are 1) Determine whether MMN is related to functioning, psychosocial recovery in VA rehabilitation milieus and programs; 2) Determine whether MMN is linked to cognition and predicts cognitive remediation exercise performance in a heterogeneous group of Veterans with mental illness. The proposal will also assess feasibility and acceptability of using biomarker-guided cognitive rehabilitation interventions in VA mental health rehabilitation settings.

Information gained from this study will help establish a precision-medicine approach towards cognitive rehabilitation for Veterans with mental illness.


Schizophrenia, Stress Disorders, Post-Traumatic, Electroencephalography, Cognition, Rehabilitation, Post-Traumatic Stress Disorders, Veterans engaged in VA mental health rehabilitation/recovery


You can join if…

Open to people ages 18 years and up

  • Veterans are currently enrolled in or within 6 weeks of discharge from (as relevant): a VA San Diego Healthcare System (VASDHS) psychosocial rehabilitation and recovery center (PRRC), VASDHS mental health residential rehabilitation treatment program (RRTP), VASDHS acute inpatient hospitalization or VASDHS outpatient mental health treatment
  • have a DSM-5 mental illness, including:
  • fluent and literate in English
  • no impairment in hearing or vision

You CAN'T join if...

  • active substance use within the last 30 days
  • positive urine drug screen conducted as part of the screening process
  • have acute/ongoing thoughts of self-harm or harming others
  • intellectual disability or a neurocognitive disorder (i.e. dementia)


  • VA San Diego Healthcare System, San Diego, CA accepting new patients
    San Diego California 92161-0002 United States

Lead Scientist at UCSD

  • Yash B. Joshi, MD PhD
    Assistant Professor in Residence, Psychiatry, Vc-health Sciences-schools. Authored (or co-authored) 41 research publications


accepting new patients
Start Date
Completion Date
VA Office of Research and Development
Study Type
Expecting 104 study participants
Last Updated