Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at San Diego, California
Dates
study started
estimated completion
Principal Investigator
by Yash B. Joshi

Description

Summary

Veterans with mental illness face challenges with community reintegration, including achieving vocational success, attaining their educational goals and going back to school, and maintaining a high quality of life. VA Mental Health Residential Rehabilitation Treatment Programs and Psychosocial Rehabilitation and Recovery Centers are designed to help Veterans overcome these barriers, but cognitive impairment often seen in Veterans with mental illness limits gains from these settings. Cognitive remediation interventions can be helpful, but they are either "one-size fits all," and thus may not be useful for all Veterans with mental illness, or are too narrow in scope, focusing on specific mental illnesses, limiting generalizability. This project will test whether an objective neurophysiological biomarker, mismatch negativity (MMN), can better match the "right" Veteran to the "right" cognitive remediation treatment regardless of their specific mental health diagnosis.

Official Title

Optimizing Cognitive Remediation in VA Mental Health Rehabilitation Settings

Details

This is an observational, non-interventional study. Veterans within 4 weeks of starting services in VA Mental Health Residential Rehabilitation Treatment Programs (RRTP) and Psychosocial Rehabilitation and Recovery Centers (PRRC) will be recruited. Veterans with PTSD and psychosis-spectrum illnesses engaged in RRTPs and PRRCs will have their cognitive functioning assessed. Following this, mismatch negativity (MMN) will be assessed via electroencephalography (EEG). Participants will undergo a 1 hour computerized cognitive training program. They will be interviewed about their attitudes about EEG and computerized cognitive training. They will be followed monthly for a total of 4 months from study entry to assess recovery trajectory. This study aims to enroll 104 Veterans from the VA San Diego Healthcare System.

The Specific Aims of this proposal are 1) Determine whether MMN is related to functioning, psychosocial recovery and treatment engagement in VA rehabilitation milieus; 2) Determine whether MMN is linked to cognition and predicts cognitive remediation exercise performance in a heterogenous group of Veterans with mental illness. The proposal will also assess feasibility and acceptability of using biomarker-guided cognitive rehabilitation interventions in VA rehabilitation settings.

Information gained from this study will help establish a precision-medicine approach towards cognitive rehabilitation for Veterans with mental illness.

Keywords

Schizophrenia Stress Disorders, Post-Traumatic Electroencephalography Cognition Rehabilitation Veterans engaged in VA mental health rehabilitation/recovery

Eligibility

You can join if…

Open to people ages 18 years and up

  • Veterans are within 4 weeks of entry in a VA San Diego Healthcare System (VASDHS) psychosocial rehabilitation and recovery center (PRRC) /mental health residential rehabilitation treatment program (RRTP)
  • have a DSM-5 mental illness, including:
  • schizophrenia
  • schizoaffective disorder
  • delusional disorder
  • major depressive disorder
  • bipolar disorder
  • generalized anxiety disorder
  • PTSD
  • fluent and literate in English
  • no impairment in hearing or vision

You CAN'T join if...

  • active substance use within the last 30 days
  • positive urine drug screen conducted as part of the screening process
  • have acute/ongoing thoughts of self-harm or harming others
  • intellectual disability or a neurocognitive disorder (i.e. dementia)

Location

  • VA San Diego Healthcare System, San Diego, CA
    San Diego California 92161 United States

Lead Scientist at UCSD

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
VA Office of Research and Development
ID
NCT04395157
Study Type
Observational
Last Updated