for people ages 55 years and up (full criteria)
at San Diego, California
study started
completion around
Principal Investigator
by Jacqueline E Maye, PhD



Veterans have numerous risk factors (e.g., PTSD, TBI, cerebrovascular problems) for later-life cognitive and functional decline. Evidence supports the effectiveness of strategy-based cognitive rehabilitation therapies, including compensatory cognitive training (CCT), for such decline. However, questions remain about the length of time that CCT-driven improvements in cognitive and everyday function last, and whether additional 'booster' training sessions could provide additional benefit to aging Veterans who previously underwent treatment. This study examines the long-term durability of CCT in Veterans aged 55+ and provides an opportunity to develop and pilot test a series of CCT booster sessions that can be personalized toward individual everyday functional goals.

Official Title

Assessing and Improving the Durability of Compensatory Cognitive Training for Older Veterans (AID-CCT)


The RCT portion of this study is a pilot trial evaluating the feasibility and acceptability of a "booster" CCT intervention for individuals who have already previously participated in CCT. 28 Veterans who previously participated in the ME-CCT intervention group of the "Cognitive Rehabilitation for Older Veterans with Mild Cognitive Impairment" study [PI: Twamley, VA CSRD: I01CX001592] will be recruited to participate in this pilot RCT.

All participants will receive an initial assessment that consists of neuropsychological and functional capacity tests, and will complete several self-reports of quality of life and daily function. Participants will complete questionnaires focused on acceptability, appropriateness, and feasibility. Participants will then be randomized to pilot RCT booster training or Treatment as Usual (TAU) group, yielding approximately 14 participants in each group. Participants will receive either three to four booster intervention modules/sessions or treatment as usual. Directly following the approximately 4-week intervention window, all 28 participants will receive the same battery of tests and questionnaires they received at the beginning of the sub-study.

Although the investigators will attempt to estimate possible initial effects of the CCT booster on cognitive and functional outcomes, the purpose of this pilot RCT is to examine feasibility and acceptability, not to complete an adequately-powered efficacy study.


Mild Cognitive Impairment, Cognitive Rehabilitation, Cognitive Training, Cognitive Remediation, Cognitive Dysfunction, Motivationally-Enhanced Compensatory Cognitive Training (ME-CCT) Booster Modules, ME-CCT Booster Training


You can join if…

Open to people ages 55 years and up

  • Veterans aged 55 and older who are able to provide informed consent
  • Previous completion of the "Cognitive Rehabilitation for Older Veterans with Mild

    Cognitive Impairment" [PI: Twamley, VA CSRD: I01CX001592] study and received the ME-CCT intervention

  • Independently living
  • English-speaking: this is necessary to complete cognitive and functional testing and participate in booster development and other study procedures

You CAN'T join if...

  • Participation in sub-study 2 of this CDA, in which study participants assist with the design of booster intervention modules
  • DSM-5 criteria for current substance use disorder and has been substance abstinent for less than 30 days
  • History of schizophrenia, schizoaffective disorder, or other primary psychotic disorder
  • History of significant brain injury with loss of consciousness >30 minutes
  • Auditory or visual impairments that would prevent ability to participate in booster sessions or ability to benefit from compensatory strategies


  • VA San Diego Healthcare System, San Diego, CA
    San Diego California 92161-0002 United States

Lead Scientist at UCSD


accepting new patients by invitation only
Start Date
Completion Date
VA Office of Research and Development
Study Type
Expecting 28 study participants
Last Updated