Effect of Anti-inflammatory Diet in Osteoarthritis

a study on Osteoarthritis

Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at San Diego, California
Dates
study started
completion around
Principal Investigator
by Monica Guma
Headshot of Monica Guma
Monica Guma

Description

Summary

In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet improves the clinical outcomes in participants with Osteoarthritis, and the role of microbiome and circulating metabolites.

Official Title

An Evaluator-blinded Randomized Controlled Trial Study of the Effect of Anti-inflammatory Diet in Subjects With Osteoarthritis

Keywords

Osteoarthritis, Knee, Osteoarthritis, Knee Osteoarthritis, Anti-Inflammatory Agents, Anti-inflammatory Diet, Healthy Diet

Eligibility

You can join if…

Open to people ages 18 years and up

  • Unilateral radiographic symptomatic KOA
  • No changes in therapy during the previous 3 months
  • Interested in dietary intervention and able to provide consent and attend follow-up visits

You CAN'T join if...

  • Previous knee surgery
  • Severe radiographic disease (KL grade 4)
  • Rheumatoid Arthritis
  • Any Abnormal blood values in the comprehensive metabolic panel test at screen (Abnormality will be defined based on standard reference ranges)
  • Use of corticosteroids and/or intra-articular injections during the preceding 3 months
  • Use of fish oils and glucosamine
  • Participation in a weight loss program in the preceding 6 months
  • Recent changes in physical activity levels
  • Regular smoking
  • Patients with food allergies
  • Patient with other medical conditions that will impair the ability to participate in a nutritional study
  • Plan to change systemic therapy
  • Patients unwilling to change dietary habits

Location

  • University of California accepting new patients
    San Diego California 92122 United States

Lead Scientist at UCSD

  • Monica Guma
    Professor In Residence, Medicine, Vc-health Sciences-schools. Authored (or co-authored) 78 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Diego
ID
NCT06080347
Study Type
Interventional
Participants
Expecting 72 study participants
Last Updated
Contact us about this trial