I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
Breast Neoplasms Breast Cancer Breast Tumors Angiosarcoma TNBC - Triple-Negative Breast Cancer HER2-positive Breast Cancer HER2-negative Breast Cancer Hormone Receptor Positive Tumor Hormone Receptor Negative Tumor Early-stage Breast Cancer Locally Advanced Breast Cancer Neoadjuvant Breast Cancer Neoplasm Adaptive pCR Pathologic Complete Response Biomarkers signature MRI Volume Endocrine Therapy Chemotherapy Immunotherapy Triple Negative Breast Neoplasms Hemangiosarcoma Metformin Paclitaxel Ado-trastuzumab emtansine Albumin-Bound Paclitaxel Carboplatin Doxorubicin Pembrolizumab Irinotecan Trastuzumab Durvalumab Letrozole Olaparib Pertuzumab Veliparib Talazoparib Cemiplimab Trebananib AMG 386 with or without Trastuzumab AMG 479 (Ganitumab) plus Metformin MK-2206 with or without Trastuzumab AMG 386 and Trastuzumab T-DM1 and Pertuzumab Pertuzumab and Trastuzumab Ganetespib ABT-888 Neratinib PLX3397 Pembrolizumab - 4 cycle Talazoparib plus Irinotecan Patritumab and Trastuzumab Pembrolizumab - 8 cycle SGN-LIV1A Durvalumab plus Olaparib SD-101 + Pembrolizumab Tucatinib plus trastuzumab and pertuzumab Cemiplimab plus REGN3767 Trilaciclib with or without trastuzumab + pertuzumab SYD985 ([vic-]trastuzumab duocarmazine) Oral Paclitaxel + Encequidar + Dostarlimab (TSR-042) + Carboplatin with or without trastuzumab Oral Paclitaxel + Encequidar + Dostarlimab (TSR-042) with or without trastuzumab Amcenestrant Amcenestrant + Abemaciclib Amcenestrant + Letrozole AMG 479 plus Metformin Pembrolizumab 4 cycle Pembrolizumab 8 cycle Tucatinib Endocrine Optimization Pilot: Amcenestrant Monotherapy Endocrine Optimization Pilot: Amcenestrant + Abemaciclib Endocrine Optimization Pilot: Amcenestrant + Letrozole
Lead Scientist at UCSD
- Anne Wallace, MD
Dr. Wallace employs nuclear and fluorescence imaging to detect and stage melanoma and breast cancer. She also employs advanced imaging techniques to study stem cell reconstructive surgery. Dr. Anne Wallace is a member of both the Division of General Surgery and the Division of Plastic Surgery. She has directed the breast program since 1995 at the UC San Diego Moores Cancer Center.