Summary

for people ages 18 years and up (full criteria)
at San Diego, California and other locations
study started
estimated completion:

Description

Summary

To study the safety and efficacy of CG0070, an oncolytic virus expression GMCSF in high grade non muscle invasive bladder cancer patients who failed BCG therapy and refused cystectomy.

Official Title

An Open Label, Single Arm, Phase II, Multicenter Study of the Safety and Efficacy of CG0070 Oncolytic Vector Regimen in Patients With Non-Muscle Invasive Bladder Carcinoma Who Have Failed BCG Therapy and Refused Cystectomy

Details

The plan is to study the safety and efficacy of CG0070 in high-grade NMIBC patients who failed BCG therapy. Most patients with NMIBCis (Cis, Cis with Ta and/or T1, high grade Ta or T1 with frequent or uncontrolled recurrences) who have failed BCG intravesical therapy (standard of care) usually have no other choice but to proceed to cystectomy. Cystectomy is a surgery associated with major morbidity, mortality and quality of life issues. Morbidity and long term tedious medical care will be for the rest of the patient's life span. Most patients at this stage do not show signs of disease progression into the muscle layer or of metastasis, making surgery a very difficult decision. CG0070, if successful in this trial, will serve to provide a therapeutic alternative for this patient population in need.

Keywords

Bladder Cancer Urinary Bladder Neoplasms CG0070

Eligibility

You can join if…

Open to people ages 18 years and up

  1. Patients must have pathologically confirmed non-muscle invasive bladder cancer (NMIBC)high grade disease (HG), as defined by the 2004 WHO classification system
  2. Patients must have no evidence of muscle invasive disease
  3. Patients must be able to provide a sufficient biopsy sample to the central pathologist for histopathologically confirmed, transitional cell (urothelial) carcinoma.Urothelial tumors with mixed histology (but with <50% variant) are eligible.
  4. Patients must have received at least two or more prior courses of intravesical therapy per recommended schedules. BCG must have been one of the prior therapies administered.
  5. Patients can have either failed BCG induction therapy within a six-month period or have been successfully treated with BCG, but subsequently found to have recurrence.The first standard course of intravesical BCG therapy must include at least six weekly treatments (allowable range of instillations per course is 4-9). The second course of BCG therapy must include at least two weekly treatments.
  6. Patients have either Cis or Cis with Ta and/or T1 disease at enrollment or in the past. For those patients with only Ta or T1 disease at enrollment AND with no history of Cis, they must have
  7. disease recurrence either must occur within 12 months of the most recent intravesical therapy of any kind, OR
  8. disease recurrence within 18 months of BCG maintenance OR
  9. disease recurrence within 24 months of BCG induction
  10. T1 patients need to have evidence of muscle included in their latest biopsy; and if not a re-TURBT has to be done prior to enrollment
  11. 18 years of age or older
  12. Radical cystectomy has been declined by the patient in a signed special section of the informed consent, whereby there is a clear explanation by the investigator to the subject that a delay of cystectomy may increase his/her chance of disease progression,the results of which may lead to serious and life threatening consequences.
  13. Patients must be able to enter into the study within ten weeks of their most recent diagnostic procedure, which is usually a diagnostic biopsy, a transurethral resection of bladder tumor (TURBT) procedure or positive urine cytology.
  14. . Eastern Cooperative Oncology Group (ECOG) performance status <2.
  15. . Not pregnant or lactating
  16. . Patients with child bearing potential must agree to use adequate contraception
  17. . Agree to study specific informed consent and HIPAA authorization for release of personal health information
  18. . Adequate baseline CBC, renal and hepatic function. Parameters described as WBC>3000 cells/mm3, ANC>1,000 cells/mm3, hemoglobin>9.5g/dL, and platelet count >100,000 cells/mm3

  19. Adequate renal function: serum creatinine <2.5mg/dL
  20. Bilirubin, AST and ALT not more than 2 x Upper Limits of Normal
  21. PT/INR, PTT, and fibrinogen within institutional acceptable limits
  22. Absolute lymphocyte count ≥ 800/μL before the first dose of CG0070

You CAN'T join if...

  1. Previous systemic chemotherapy or radiation for bladder cancer. Note: Prior immunotherapy or intravesical (administered within the bladder) chemotherapy for superficial disease is acceptable
  2. History of anaphylactic reaction following exposure to humanized or human therapeutic monoclonal antibodies, hypersensitivity to GM-CSF or yeast derived products,clinically meaningful allergic reactions or any known hypersensitivity or prior reaction to any of the formulation excipients in the study drugs.
  3. Known infection with HIV, HBV or HCV.
  4. Anticipated use of chemotherapy or radiotherapy not specified in the study protocol while on study
  5. Any underlying medical condition that, in the Investigator's opinion, will make the administration of study vector hazardous to the patient, would obscure the interpretation of adverse events, or not permit adequate surgical resection.
  6. Systemic treatment on any investigational clinical trial within 28 days prior to registration.
  7. Concurrent treatment with immunosuppressive or immunomodulatory agents, including any systemic steroid (exception: inhaled or topically applied steroids, and acute and chronic standard dose NSAIDs, are permitted). Use of a short course (i.e., ≤ 1 day) of a glucocorticoid is acceptable to prevent a reaction to the IV contrast used for CT scans.
  8. Immunosuppressive therapy, including: cyclosporine, antithymocyte globulin, or tacrolimus within 3 months of study entry.
  9. History of prior experimental cancer vaccine treatment (e.g., dendritic cell therapy,heat shock vaccine) within the last year
  10. . History of stage III or greater cancer, excluding urothelial cancer. Basal or squamous cell skin cancers must have been adequately treated and the subject must be disease-free at the time of registration. Subjects with a history of stage I or II cancer, must have been adequately treated and have been disease-free for ≥ 2 years at the time of registration.
  11. . Progressive or persistent viral or bacterial infection
  12. All infections must be resolved and the patient must remain afebrile for seven days without antibiotics prior to being placed on study
  13. Urinary tract infection, including particularly bladder infection, must be resolved prior to being placed on study
  14. . Unwilling or unable to comply with the protocol or cooperate fully with the investigator and site personnel

Locations

  • University of California, San Diego
    San Diego California 92093 United States
  • UC Irvine Medical Center
    Orange California 92868 United States
  • Institute of Urologic Oncology at UCLA
    Los Angeles California 90095 United States

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Cold Genesys, Inc.
ID
NCT02365818
Phase
Phase 2
Study Type
Interventional
Last Updated
August 2017