for people ages 60-80 (full criteria)
healthy people welcome
at La Jolla, California
study started
estimated completion
Amy Jak



Vast evidence supports use of physical exercise and cognitive stimulation for lowering risk for cognitive decline and dementia, with combinations of non-pharmacological interventions providing greatest promise for impacting cognitive aging. This, paired with limited cognitive benefits from pharmacological interventions in dementia, has shifted focus to non-pharmacological interventions administered earlier in the disease course. This application, therefore, proposes a randomized controlled trial (RCT; 12-week active intervention, 3- and 6-month follow-up) comparing 3 conditions: walking program (guided progressive increases in weekly step counts), computer-based cognitive training program (Brain HQ, Posit Science), and combination of the exercise and cognitive program, on cognitive, functional, and diagnostic outcomes in 60 sedentary, community-dwelling adults with mild cognitive impairment (MCI).


Mild Cognitive ImpairmentCognitive DysfunctionWalking InterventionCognitive Training InterventionCombined Intervention


You can join if…

Open to people ages 60-80

  • MCI diagnosis (can be self referral, will determine eligibility at baseline)

You CAN'T join if...

  • Dementia diagnosis
  • Head trauma
  • Neuro/psychiatric disorders
  • Current substance dependence
  • Sensory/mobility deficits
  • No more than 1 hour of purposeful, aerobic activity/week
  • Currently engaging in any other brain-stimulating computer program (No more than 1 hour a week)


  • UCSD
    La JollaCalifornia92037United States

Lead Scientist

  • Amy Jak
    Dr. Jak received her doctorate in Clinical Psychology, with specialization in neuropsychology, from the University of Cincinnati (2004). She completed a postdoctoral fellowship in neuropsychology at the VA San Diego Healthcare System/Veteran’s Medical Research Foundation from 2004-2007.


in progress, not accepting new patients
Start Date
Completion Date
University of California, San Diego
Study Type
Last Updated