for people ages 60-80 (full criteria)
healthy people welcome
at La Jolla, California
study started
estimated completion:
Amy Jak



Vast evidence supports use of physical exercise and cognitive stimulation for lowering risk for cognitive decline and dementia, with combinations of non-pharmacological interventions providing greatest promise for impacting cognitive aging. This, paired with limited cognitive benefits from pharmacological interventions in dementia, has shifted focus to non-pharmacological interventions administered earlier in the disease course. This application, therefore, proposes a randomized controlled trial (RCT; 12-week active intervention, 3- and 6-month follow-up) comparing 3 conditions: walking program (guided progressive increases in weekly step counts), computer-based cognitive training program (Brain HQ, Posit Science), and combination of the exercise and cognitive program, on cognitive, functional, and diagnostic outcomes in 60 sedentary, community-dwelling adults with mild cognitive impairment (MCI).


Mild Cognitive Impairment Cognitive Dysfunction Walking Intervention Cognitive Training Intervention Combined Intervention


You can join if…

Open to people ages 60-80

  • MCI diagnosis (can be self referral, will determine eligibility at baseline)

You CAN'T join if...

  • Dementia diagnosis
  • Head trauma
  • Neuro/psychiatric disorders
  • Current substance dependence
  • Sensory/mobility deficits
  • No more than 1 hour of purposeful, aerobic activity/week
  • Currently engaging in any other brain-stimulating computer program (No more than 1 hour a week)


  • UCSD
    La Jolla California 92037 United States

Lead Scientist

  • Amy Jak
    Dr. Jak received her doctorate in Clinical Psychology, with specialization in neuropsychology, from the University of Cincinnati (2004). She completed a postdoctoral fellowship in neuropsychology at the VA San Diego Healthcare System/Veteran’s Medical Research Foundation from 2004-2007.


in progress, not accepting new patients
Start Date
Completion Date
University of California, San Diego
Study Type
Last Updated