Prospective single arm study to evaluate a low-dose CT-based protocol for early detection of myocardial dysfunction in 50 cancer patients undergoing anthracycline-based chemotherapy.
NeoplasmsCardiotoxicitylow dose CT
You can join if…
Open to people ages 18-75
Ability to understand and the willingness to sign a written informed consent.
18-75 year old patients with newly-diagnosed cancer scheduled to undergo anthracycline-based chemotherapy (minimum of 200 mg/m2 of doxorubicin or equivalent)at UCSD Medical Center.
Women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.
• A woman of child-bearing potential is any female (regardless of sexual orientation,having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria:
Has not undergone a hysterectomy or bilateral oophorectomy; or
Has not been naturally postmenopausal for at least 12 consecutive months (i.e.,has had menses at any time in the preceding 12 consecutive months)
Women of child-bearing potential must have a negative pregnancy test during the screening period.
You CAN'T join if...
Prior chemotherapy with anthracycline;
Persistent tachycardia (heart rate>90);
LVEF<53% or history of cardiomyopathy or decompensated heart failure;
Baseline GLS below lower limit of normal (normal range varies depending on age and gender (23)) or inability to obtain meaningful strain data due to poor quality of Echocardiographic images;
Known unrevascularized coronary artery disease, myocardial infarction within 30 days of enrollment;
Moderate or severe valvular heart disease;
Prior allergy or intolerance to iodinated contrast;
Renal failure (GFR<30, creatinine >1.5);
Cancer involvement of the heart.
University of California San Diego Medical Centeraccepting new patients San DiegoCalifornia92037United States