for people ages 18-75 (full criteria)
at San Diego, California
study started
estimated completion
Principal Investigator
by Anna Narezkina, MD



Prospective single arm study to evaluate a low-dose CT-based protocol for early detection of myocardial dysfunction in 50 cancer patients undergoing anthracycline-based chemotherapy.


Neoplasms Cardiotoxicity low dose CT


You can join if…

Open to people ages 18-75

  1. Ability to understand and the willingness to sign a written informed consent.
  2. 18-75 year old patients with newly-diagnosed cancer scheduled to undergo anthracycline-based chemotherapy (minimum of 200 mg/m2 of doxorubicin or equivalent) at UCSD Medical Center.
  3. Women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.

• A woman of child-bearing potential is any female (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria:

  • Has not undergone a hysterectomy or bilateral oophorectomy; or
  • Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months)
  • Women of child-bearing potential must have a negative pregnancy test during the screening period.

You CAN'T join if...

  1. Prior chemotherapy with anthracycline;
  2. Persistent tachycardia (heart rate>90);
  3. LVEF<53% or history of cardiomyopathy or decompensated heart failure;
  4. Baseline GLS below lower limit of normal (normal range varies depending on age and gender (23)) or inability to obtain meaningful strain data due to poor quality of Echocardiographic images;
  5. Known unrevascularized coronary artery disease, myocardial infarction within 30 days of enrollment;
  6. Moderate or severe valvular heart disease;
  7. Prior allergy or intolerance to iodinated contrast;
  8. Renal failure (GFR<30, creatinine >1.5);
  9. Cancer involvement of the heart.


  • University of California San Diego Medical Center
    San Diego California 92037 United States

Lead Scientist at UCSD


in progress, not accepting new patients
Start Date
Completion Date
University of California, San Diego
Study Type
Last Updated