Summary

for people ages 18-70 (full criteria)
at La Jolla, California
study started
estimated completion:
Jeremy Pettus

Description

Summary

The purpose of this research study will be to test and evaluate if dapagliflozin has an effect on the amount of glucagon (a hormone produced by the pancreas and stomach that stimulates liver glucose production) produced by the body and if that change will improve recovery time from hypoglycemia (low blood sugar) in participants with Type 1 Diabetes.

Official Title

Evaluating the Effect of Dapagliflozin, an SGLT-2 Inhibitor, on the Counterregulatory Response to Hypoglycemia in Individuals With Type 1 Diabetes

Details

The purpose of this research study will be to test and evaluate if dapagliflozin has an effect on the amount of glucagon (a hormone produced by the pancreas and stomach that stimulates liver glucose production) produced by the body and if that change will improve recovery time from hypoglycemia (low blood sugar) in participants with Type 1 Diabetes. The study is a blinded, placebo-controlled, crossover design, where participants will receive dapagliflozin during one treatment period and placebo during a separate treatment period with neither the study team nor participants knowing what they are receiving at any given time. Participants will have 9 clinic visits over the course of 14-16 weeks, with 3 of those visits being overnight stays. The overnight stays are intended to control blood sugars in a normal state throughout the night and then participants will complete a hypoglycemic challenge the following morning. The body's response to the hypoglycemic challenge will provide the information needed to determine if dapagliflozin had an effect on recovery time from hypoglycemia.

Keywords

Type1 Diabetes Mellitus Diabetes Mellitus Diabetes Mellitus, Type 1 Hypoglycemia Dapagliflozin 5mg

Eligibility

You can join if…

Open to people ages 18-70

  1. Signed and dated written informed consent by the date of Visit 1 in accordance with Good Clinical Practice (GCP) and local legislation
  2. Male or female patient receiving insulin for the treatment of documented diagnosis of T1DM for at least 1 year at the time of Visit 1
  3. Non-fasting C-peptide < 0.7 ng/mL at Visit 1
  4. HbA1c ≤ 10.0% at Visit 1
  5. Based on the Investigator's judgment patient must have a good understanding of his/her disease and how to manage it, and be willing and capable of performing the following study assessments (assessed at Visits 1):
  6. patient-led management and adjustment of insulin therapy
  7. reliable approach to insulin dose adjustment for meals, such as carbohydrate counting
  8. reliable and regular home-based blood glucose monitoring
  9. be able to perform ketone sample measurement when feeling ill and/or nauseated
  10. implementation of an established "sick day" management regimen
  11. Age ≥ 18 and ≤ 70 years at Visit 1
  12. Body Mass Index (BMI) of 18.5 kg/m2 to 35.0 kg/m2 at Visit 1
  13. eGFR ≥ 60 mL/min/1.73m²
  14. Patients must be able and willing to perform study assessments

You CAN'T join if...

  1. History of T2DM, maturity onset diabetes of the young (MODY), pancreatic surgery or chronic pancreatitis
  2. Pancreas, pancreatic islet cells or renal transplant recipient
  3. T1DM treatment with any other antihyperglycemic drug (e.g. metformin, alpha- glucosidase inhibitors, SGLT-2 inhibitors, pramlintide, inhaled insulin, pre-mixed insulins, etc.) within 30 days of run-in (visit 2)
  4. Occurrence of severe hypoglycemia involving coma and/or seizure that required hospitalization or hypoglycemia-related treatment by an emergency physician or paramedic within 3 months prior to Visit 1 or Visit 2
  5. Occurrence of DKA within 3 months prior to Visit 1 or Visit 2
  6. Acute coronary syndrome (non-STEMI, STEMI and unstable angina pectoris), stroke or transient ischemic attack (TIA) within 3 months prior to Visit 1 or Visit 2
  7. Indication of liver disease, defined by serum levels of either alanine transaminase(ALT), aspartate transaminase (AST), or alkaline phosphatase above 3 x upper limit of normal (ULN) at Visit 1
  8. Current signs and symptoms of anemia accompanied by a hemoglobin laboratory value at or below 10.0 g/dL at screening.
  9. Eating disorders such as bulimia or anorexia nervosa
  10. . Treatment with systemic corticosteroids within 30 days of run-in (visit 2), or planned initiation of such therapy at Visit 1 or Visit 2. Inhaled or topical use of corticosteroids (e.g. for asthma/chronic obstructive pulmonary disease) is acceptable.
  11. . Medical history of cancer or treatment for cancer in the last five years prior to Visit 1. Resected basal cell carcinoma considered cured is exempted.
  12. . Women who are pregnant, nursing, or who plan to become pregnant while in the trial
  13. . Intake of an investigational drug in another trial within 30 days prior to Visit 1
  14. . Patient not able to understand and comply with study requirements, based on Investigator's judgment
  15. . Any other clinical condition that, based on Investigator's judgment, would jeopardize patient safety during trial participation or would affect the study outcome (e.g.immunocompromised patients who might be at higher risk of developing genital or mycotic infections, patients with chronic viral infections etc.)

Location

  • UC San Diego Altman Clinical & Translational Research Institute accepting new patients
    La Jolla California 92037 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Diego
ID
NCT03704818
Phase
Phase 1
Lead Scientist
Jeremy Pettus
Study Type
Interventional
Last Updated