Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at San Diego, California
Dates
study started
completion around
Principal Investigator
by Leslie Morland
Headshot of Leslie Morland
Leslie Morland

Description

Summary

The goal of this pilot trial is to examine the preliminary effectiveness of MDMA-facilitated bCBCT for improving chronic PTSD and relationship functioning in a sample of veterans and their intimate partners seeking care within the VA San Diego Healthcare System.

Details

The pilot study is a single site, open-label study assessing the preliminary effectiveness, safety, and acceptability of MDMA-assisted therapy in combination with brief Cognitive Behavioral Conjoint Therapy in a sample of 8 veterans diagnosed with PTSD and their intimate partners (N = 16) within the VASDHS system. Therapy teams will deliver the 8 session bCBCT intervention combined with two full-day MDMA sessions for the Veteran diagnosed with PTSD. The veteran with PTSD will be given 80 mg of MDMA HCl with a 40 mg MDMA HCl supplemental dose in the first session and 100 mg of MDMA HCl with a supplemental dose of 40 mg MDMA HCl in the second. The intimate partner will be present for the MDMA sessions (unless they decline or it is clinically contraindicated) but will not receive MDMA. The couples will complete one preparatory session as part of their bCBCT and two Emotion Focused Integrative sessions and the PTSD+ veteran will receive telephone check-in calls every other business day for one week following each MDMA session. The first MDMA session occurs in the morning the business day after the preparatory session (bCBCT sessions 1-3 massed with a preparatory session) and the second MDMA session occurs in the morning 1-2 business days after bCBCT Session 6. The Emotion-Focused Integrative Sessions take place the morning after each MDMA session. Outcomes examining PTSD symptom severity and relationship functioning will be evaluated for preliminary effectiveness. The study's screening, enrollment, and baseline phase lasts from pre-screen to baseline (approximately 12 weeks, +/- 2 weeks). The treatment period lasts from bCBCT Session 1 to bCBCT Session 8 (7 weeks + 6 weeks). The follow-up period lasts from the post-treatment assessment to study termination (24 weeks +/- 30 days).

Keywords

PTSD, Relational Problems, Intimate relationships, MDMA, Post-Traumatic Stress Disorders, 3,4-methyllenedioxymethamphetamine (MDMA), Brief Cognitive Behavioral Conjoint Therapy (bCBCT)

Eligibility

You can join if…

Open to people ages 18 years and up

  1. Be a veteran (age 18 years or older) who meets criteria for PTSD on the CAPS-5 or be an intimate partner (age 18 or older) of a veteran meeting the criteria for PTSD who is willing to participate in the intervention and who does not meet criteria for PTSD on the PCL-5 (i.e., must score a 30 or lower).
  2. Be in a committed relationship together of at least 12 months, and be cohabiting.
  3. Be fluent in speaking and reading English.
  4. Are willing to commit to medication dosing, therapy sessions, follow-up sessions, completing evaluation instruments, and all necessary telephone contact.
  5. Be able to swallow pills. (PTSD+ veteran only)
  6. Agree to have study visits recorded, including Experimental MDMA Sessions, and be aware that Independent Rater assessments for bCBCT sessions will occur.
  7. Provide a contact (relative, spouse, close friend, or other support person) who is willing and able to be reached by the investigators in the event of a participant becoming suicidal or unreachable. (PTSD+ veteran only)
  8. Agree to inform the investigators within 48 hours of any new medical conditions or procedures.
  9. If able to become pregnant (i.e., assigned female at birth, fertile, following menarche and until becoming post-menopausal unless permanently sterile), must have a highly sensitive negative pregnancy test at study entry and prior to each Experimental MDMA Session, and must agree to use adequate birth control through 10 days after the last Experimental MDMA Session. Adequate birth control methods include intrauterine device (IUD), injected, implanted, intravaginal, or transdermal hormonal methods, abstinence, oral hormones plus a barrier contraception, vasectomized sole partner, or double barrier contraception. Two forms of contraception are required with any barrier method or oral hormones (i.e., condom plus diaphragm, condom or diaphragm plus spermicide, oral hormonal contraceptives plus spermicide or condom). (PTSD+ veteran only)

    10. Agree to the following lifestyle modifications: comply with requirements for fasting

    and refraining from certain medications prior to Experimental MDMA Sessions. (PTSD+ veteran only)

    11. Not enroll in any other interventional clinical trials during the duration of the

    study, and commit to medication dosing, therapy, and study procedures.

    12. Both partners agree to not begin a new form of mental healthcare during the screening

    or treatment phases of the trial, without first discussing with the PI in consultation with the study physician.

    1. It is acceptable for participants to continue ongoing non-PTSD focused or non-couple-based mental healthcare, if it is not increased in frequency or specifically excluded by the study protocol.
    2. All ongoing therapies should be documented by the site and discussed with the study physician prior to enrollment to avoid confounding treatment effects. In some instances, the study physician may request that the participant delay enrollment until their planned course of therapy is complete, and an integration period has elapsed.

    Medical History - PTSD+ veteran only unless otherwise noted

    13. At Pre-Screening, have at least moderate PTSD symptoms in the last month based on

    PCL-5 total score of 40 or greater (index).

    14. May have well-controlled hypertension that has been successfully treated with anti-

    hypertensive medicines if they pass additional screening to rule out underlying cardiovascular disease.

    15. May have asymptomatic Hepatitis C virus (HCV) that has previously undergone evaluation

    and treatment as needed.

    16. At Screening, have at least moderate PTSD per CAPS-5 and symptoms in the last month

    constituting a CAPS-5 Total Severity Score of 28 or greater (index).

    17. May have alcohol or substance use disorder if participant is not in withdrawal or

    requiring detox. Participants/couples must have a plan, agreed upon by investigator, therapy team, and study physician, to reduce use of alcohol or other substances and to manage symptoms without self-medicating. Enrollment will require that, in the judgment of the investigator, therapy team, and study physician, the plan for decreasing substance use is realistic and has a good chance of succeeding in order to prevent substance use from impacting the safety or effectiveness of the investigational treatment. (Both partners)

    18. May have a history of or current Diabetes Mellitus (Type 2) if additional screening

    measures rule out underlying cardiovascular disease, if the condition is judged to be stable on effective management, and with approval by the study physician.

    19. May have hypothyroidism if taking adequate and stable thyroid replacement medication. 20. May have a history of, or current, glaucoma if approval for study participation is

    received from an ophthalmologist.

You CAN'T join if...

  1. Are not able to give adequate informed consent.
  2. Are currently engaged in compensation and pension (C&P) litigation whereby financial gain would be achieved from prolonged symptoms of PTSD or any other psychiatric disorders.
  3. Are likely, in the investigator's opinion and via assessment period, to be re- exposed to their index trauma or other significant trauma, lack social support, or lack a stable living situation
  4. Have used Ecstasy (material represented as containing MDMA) more than 10 times within the last 10 years or at least once within 6 months of the first Experimental MDMA Session. (PTSD+ veteran only)
  5. Have any current problem which, in the opinion of the investigator or study physician, might interfere with participation due to it impacting the patient's safety and/or ability to participate in the protocol
  6. Have hypersensitivity to any ingredient of the IMP (Investigational Medicinal Product). (PTSD+ veteran only)

    Psychiatric History - both members of dyad unless otherwise noted

  7. Have received Electroconvulsive Therapy (ECT) within 12 weeks of enrollment. (PTSD+ veteran only)
  8. Have a history of or a current primary psychotic disorder assessed via the DIAMOND and clinical interview
  9. Have a history of or a current Bipolar I disorder, Bipolar 2 disorder, or manic episode assessed via the DIAMOND and clinical interview (PTSD+ veteran only)

    10. Have a current eating disorder with active purging assessed via DIAMOND and clinical

    interview. (PTSD+ veteran only)

    11. Have current major depressive disorder with psychotic features assessed via DIAMOND 12. Have current panic disorder assessed via DIAMOND (PTSD+ veteran only) 13. Have a current alcohol or substance use disorder other than caffeine or nicotine that

    the investigators, therapy team, and/or study physician judge to be a safety concern for enrollment in the study or that could interfere with the therapeutic process or with other aspects of study participation. Any participant who is not able to agree or adhere to a plan to reduce use and manage symptoms will not be enrolled

    14. Present with current serious suicide risk, as determined through psychiatric

    interview, responses to C-SSRS (scores of four or greater), and clinical judgment of the investigator; however, history of suicide attempts is not an exclusion. Any participant who is likely to require hospitalization related to suicidal ideation and behavior, in the judgment of the investigator, will not be enrolled. Any participant presenting with the following on the pre-screen C-SSRS will be excluded:

    1. Suicidal ideation score of 4 or greater within the last 6 months of the assessment at a frequency of once a week or more
    2. Any suicidal behavior, including suicide attempts or preparatory acts, within the last 6 months of the assessment. Participants with non-suicidal self- injurious behavior may be included if approved by the study physician
      1. Report intimate partner violence or severe relationship aggression, as defined by meeting either of the following criteria:
    3. A score of 10+ on the E-HITS screening tool
    4. A score of "severe" on the Psychological Aggression scale of the Revised Conflict Tactics Inventory (CTS-2)
      1. Would present a serious risk to others as established through clinical interview and if necessary, discussion with treating psychiatrist
        1. Require ongoing concomitant therapy with a psychiatric medication other than the exceptions described in protocol section on Concomitant Therapy. (PTSD+ veteran)

    Medical History - PTSD+ veteran only

    18. Have a history of any medical condition that could make receiving a sympathomimetic

    drug harmful because of increases in blood pressure and heart rate. This includes, but is not limited to, a history of myocardial infarction, cerebrovascular accident, or aneurysm. Participants with other mild, stable chronic medical problems may be enrolled if the study physician and PI agree the condition would not significantly increase the risk of MDMA administration or be likely to produce significant symptoms during the study that could interfere with study participation or be confused with side effects of the IMP. Examples of stable medical conditions that could be allowed include, but are not limited to Diabetes Mellitus (Type 2), Human Immunodeficiency Virus (HIV) infection, Gastroesophageal Reflux Disease (GERD), etc. Any medical disorder judged by the investigator to significantly increase the risk of MDMA administration by any mechanism would require exclusion.

    19. Have a diagnosis of uncontrolled hypertension defined by the American Heart

    Association as repeated readings of ≥ 140 millimeters of Mercury [mmHg] systolic or ≥ 90 mmHg diastolic

    20. Have a history of ventricular arrhythmia at any time, other than occasional premature

    ventricular contractions (PVCs) in the absence of ischemic heart disease

    21. Have Wolff-Parkinson-White syndrome or any other accessory pathway that has not been

    successfully eliminated by ablation

    22. Have a history of arrhythmia, other than premature atrial contractions (PACs) or

    occasional PVCs in the absence of ischemic heart disease, within 12 months of screening. Participants with a history of atrial fibrillation, atrial tachycardia, atrial flutter or paroxysmal supraventricular tachycardia or any other arrhythmia associated with a bypass tract may be enrolled only if they have been successfully treated with ablation and have not had recurrent arrhythmia for at least one year off all antiarrhythmic drugs and confirmed by a cardiologist

    23. Have a marked Baseline prolongation of QT/QTc interval. For purposes of eligibility,

    this is defined as repeated demonstration of a QT interval corrected using Fridericia's formula [QTcF] >450 milliseconds [ms]

    24. Have a history of additional risk factors for Torsade de pointes (e.g., heart failure,

    hypokalemia, family history of Long QT Syndrome)

    25. Require use of concomitant medications that prolong the QT/QTc interval during

    Sessions. Refer to protocol section on Concomitant Medications

    26. Have symptomatic liver disease or have significant liver enzyme elevations 27. Have history of hyponatremia or hyperthermia 28. Weigh less than 48 kilograms (kg) 29. Are pregnant or nursing or are able to become pregnant and are not practicing an

    effective means of birth control

    30. Have engaged in ketamine-assisted therapy or used ketamine within 12 weeks of

    enrollment

    31. Have any preexisting conditions that can affect renal functioning

Location

  • VA San Diego Healthcare System, San Diego, CA accepting new patients
    San Diego California 92161 United States

Lead Scientist at UCSD

  • Leslie Morland
    Dr. Leslie Morland is a clinical psychologist and a senior researcher at the VA National Center for PTSD (NCPTSD) Women’s Health Science Division and a Professor of Psychiatry in the School of Medicine at the University of California, San Diego (UCSD). Dr. Morland served as the Chief of Outpatient Access and Director of Telemental Health for the VA San Diego Healthcare System for the past 9 years.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Dr. Leslie Morland
ID
NCT05979844
Phase
Phase 3 research study
Study Type
Interventional
Participants
Expecting 16 study participants
Last Updated