This study is not yet accepting patients

Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty

a study on Postoperative Pain Surgery Knee Replacement

Summary

Eligibility
for people ages 18 years and up (full criteria)
Dates
study started
completion around
Principal Investigator
by Rodney Gabriel
Headshot of Rodney Gabriel
Rodney Gabriel

Description

Summary

This is a single-center pilot study to determine if an adductor canal continuous nerve block is superior to single injection nerve block following total knee arthroplasty. Investigators will randomize participants to either continuous nerve block or single injection nerve block for the adductor canal preoperatively. They will assess differences in pain (measured in numeric rating scale), opioid consumption, and physical therapy milestones from postoperative day 0 to 7.

Official Title

A Pilot Randomized Controlled Trial Assessing Pain and Opioid Outcomes Among Patients Undergoing Total Knee Arthroplasty Receiving 5-Day Outpatient Adductor Canal Continuous Versus Single Injection Blocks

Details

Adductor canal blocks are standard care for postoperative analgesia following total knee arthroplasty. Adductor canal blocks involve depositing local anesthetic (ropivacaine) around the saphenous nerve at the location of the adductor canal on the ipsilateral thigh. At UCSD, the standard care is to perform single injection adductor canal blocks for research participants undergoing total knee arthroplasty prior to surgery in the preoperative waiting area.

Participants will be randomized to either: (1) single injection with ropivacaine (0.5%) of the adductor canal block AND a 5-day continuous perineural infusion of ropivacaine (0.2%) (experimental group); versus (2) single injection with ropivacaine (0.5%) of the adductor canal block and no continuous nerve block added.

Keywords

Acute Postoperative Pain, Surgery, regional anesthesia, total knee arthroplasty, nerve block, Postoperative Pain, continuous peripheral nerve block with OnQ pump, single injection nerve block, Continuous adductor canal block, single injection adductor canal block

Eligibility

You can join if…

Open to people ages 18 years and up

  1. Adult participants of at least 18 years of age
  2. Undergoing a primary, unilateral, total knee arthroplasty
  3. Planned single-injection adductor canal nerve block
  4. Weight > 50 kg (to minimize the risk of local anesthetic toxicity)

You CAN'T join if...

  1. chronic opioid or tramadol use: daily oxycodone equivalents > 20 mg for > 4 weeks
  2. neuro-muscular deficit of the surgical limb
  3. moderate pain (NRS > 3) in an anatomic location other than the surgical site
  4. planned hospital admission following surgery
  5. history of opioid misuse
  6. those who lack capacity to complete informed consent
  7. inability to contact the investigators during the treatment period, and vice versa (e.g., lack of telephone access)
  8. incarceration
  9. pregnancy
  10. allergy to amide local anesthetics

Lead Scientist at UCSD

  • Rodney Gabriel
    Dr. Rodney A. Gabriel is a tenured Associate Professor (Ladder Rank/In Residence) of Anesthesiology and Associate Adjunct Professor in Biomedical Informatics. He is the Vice-Chair of Perioperative Informatics and Clinical Director of Anesthesiology at the Koman Outpatient Pavilion Ambulatory Surgery Center.

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Diego
ID
NCT06784882
Phase
Phase 4 research study
Study Type
Interventional
Participants
Expecting 40 study participants
Last Updated