Post-Traumatic Stress Disorder clinical trials at UCSD
18 in progress, 12 open to eligible people
Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD
open to eligible people ages 18-75
Posttraumatic Stress Disorder (PTSD) remains a salient and debilitating problem, in the general population and for military veterans in particular. Several psychological and pharmacological treatments for PTSD have evidence to support their…
San Diego, California and other locations
Cannabidiol and Prolonged Exposure
open to eligible people ages 18 years and up
The trial will include a randomized control trial to evaluate the efficacy of using Cannabidiol (CBD), a non-intoxicating cannabinoid, as an adjunctive to Prolonged Exposure therapy (PE). The trial will compare PE + CBD to PE + placebo in a sample…
San Diego, California
Cognitive Control Training for Extinction in PTSD
open to eligible people ages 18-65
The proposed study will test whether a working memory training (WMT) program improves fear extinction learning and its underlying neural circuitry in Veterans with posttraumatic stress disorder (PTSD). WMT is designed to improves the ability to…
San Diego, California
Compassion Meditation vs. Health Education for Veterans
open to eligible people ages 18 years and up
Chronic pain (CP) is a major health problem for military Veterans, and CP is often associated with comorbid mental health problems, including posttraumatic stress disorder (PTSD) and depression. CP with psychological comorbidity is associated with…
San Diego, California
Enhancing Rehabilitation for Veterans With Serious Mental Illness
open to eligible people ages 18-75
This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs). The vast majority of individuals with SMI…
San Diego, California
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
open to eligible people ages 21-55
The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two…
San Diego, California
Intranasal Oxytocin Augmentation of Brief Couples Therapy for Veterans With PTSD
open to eligible people ages 18 years and up
Leveraging veterans' intimate relationships during treatment for posttraumatic stress disorder (PTSD) has the potential to concurrently improve PTSD symptoms and relationship quality. Brief Cognitive-Behavioral Conjoint Therapy (bCBCT) is a…
San Diego, California
MDMA-assisted Brief Cognitive Behavioral Conjoint Therapy for PTSD
open to eligible people ages 18 years and up
The goal of this pilot trial is to examine the preliminary effectiveness of MDMA-facilitated bCBCT for improving chronic PTSD and relationship functioning in a sample of veterans and their intimate partners seeking care within the VA San Diego…
San Diego, California
MDMA-assisted Massed Prolonged Exposure for PTSD
open to eligible people ages 18-64
The overall objective of this study is to pilot the VASDHS-adapted Emory MDMA-PE Protocol (aE-MDMA-PE) and assess the effect on clinician-rated PTSD symptoms in veterans who receive full-dose MDMA and veterans who receive low-dose MDMA.
San Diego, California
National Adaptive Trial for PTSD Related Insomnia
open to eligible people ages 18-75
Many Veterans with posttraumatic stress disorder (PTSD) have trouble sleeping or have frequent nightmares. So far, no medication has been approved for treatment of insomnia in PTSD. The purpose of this research study is to find out if taking…
San Diego, California and other locations
Non-Inferiority Trial of TrIGR for PTSD
open to eligible people ages 18 years and up
Trauma-related guilt is common and impairing among trauma survivors, particularly among Veterans with posttraumatic stress disorder (PTSD). The investigators' work shows that a brief treatment targeting trauma-related guilt, Trauma Informed Guilt…
San Diego, California and other locations
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
open to eligible people ages 18 years and up
Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone. This is especially true in…
San Diego, California
Computational Assessment of GABA Receptor Modulation in PTSD
Sorry, not yet accepting patients
A substantial majority of Veterans with posttraumatic stress disorder (PTSD) continue to suffer even with the best current medications. Progress in developing more effective medications is hampered by the substantial variability within Veterans with …
San Diego, California
Massed Prolonged Exposure for PTSD in Substance Use Treatment
Sorry, not yet accepting patients
The goal of this clinical trial is to learn if receiving Prolonged Exposure Therapy for PTSD in massed format (multiple sessions weekly) is as effective as receiving it with sessions once per week among veterans with PTSD and substance use disorder…
San Diego, California and other locations
Sequenced Treatment Effectiveness for Posttraumatic Stress
Sorry, in progress, not accepting new patients
Individuals with PTSD are more likely to engage in unhealthy behaviors such as tobacco use, drug use, alcohol misuse, and have high rates of morbidity/mortality. PTSD negatively impacts marriages, educational attainment, and occupational…
San Diego, California and other locations
Transcendental Meditation in Veterans and First Responders With PTSD
Sorry, in progress, not accepting new patients
The present study is part of a Phase 3 multi-site clinical trial that will recruit veterans and first responders diagnosed with PTSD, where they will be randomized to receive either Transcendental Meditation (TM) or Present Centered Therapy (PCT).…
La Jolla, California and other locations
Latent Structure of Multi-level Assessments and Predictors of Outcomes for Women in Recovery
Sorry, in progress, not accepting new patients
In this study the investigators will seek to improve their understanding of how positive and negative valence systems, cognition, and arousal/interoception are inter-related in disorders of trauma, mood, substance use, and eating behavior for women…
Optimizing Cognitive Remediation
Sorry, in progress, not accepting new patients
Veterans with mental illness face challenges with community reintegration, including achieving vocational success, attaining their educational goals and going back to school, and maintaining a high quality of life. VA Mental Health Residential…
San Diego, California
Our lead scientists for Post-Traumatic Stress Disorder research studies include Brian Martis, MD Yash B. Joshi, MD PhD Jonathan R Howlett, MD Leslie Morland Gregory Light, PhD Anne L Malaktaris Daniel M Stout, PhD Sonya B. Norman, PhD Jessica Bomyea Catherine R Ayers, PhD.
Last updated: