Summary

for people ages 18 years and up (full criteria)
at La Jolla, California and other locations
study started
estimated completion:

Description

Summary

This is a randomized, active-controlled, multicenter, open-label, parallel groups, Phase 2 study of DSP-7888 Dosing Emulsion plus Bevacizumab versus Bevacizumab alone in patients with recurrent or progressive glioblastoma multiforme (GBM) following treatment with first line therapy consisting of surgery and radiation with or without chemotherapy.

Official Title

A Randomized, Multicenter, Phase 2 Study of DSP-7888 Dosing Emulsion in Combination With Bevacizumab Versus Bevacizumab Alone in Patients With Recurrent or Progressive Glioblastoma Following Initial Therapy

Keywords

Glioblastoma Wilms Tumor 1 Cancer Vaccines Neoplasms Bevacizumab DSP-7888 Dosing Emulsion

Eligibility

You can join if…

Open to people ages 18 years and up

  1. Patients or their legal representatives must be able to provide written informed consent.
  2. Histologically confirmed diagnosis of supratentorial GBM (Grade 4 astrocytoma).
  3. Radiographic evidence of first recurrence or progression of GBM following primary therapy consisting of surgery (biopsy or resection) and chemoradiation; patients may have undergone a second debulking surgery following initial recurrence or progression.Patients whose tumors are O6 methyl guanyl-methyl-transferase (MGMT)methylated-promoter negative need not have received chemotherapy in the past to be eligible.
  4. Human leukocyte antigen type HLA-A02:01, HLA-A02:06, or HLA-A*24:02.

  5. Age ≥18.
  6. KPS score of ≥60.
  7. Serum creatinine value <2X the upper limit of normal (ULN) for the reference laboratory.
  8. Alanine aminotransferase/aspartate aminotransferase <3X the ULN and total bilirubin<2× the ULN for the reference laboratory.
  9. Patients must have recovered from the effect of all prior therapy to Grade 2 or less.
  10. . Patients must be at least 28 days from any major surgery, and any surgery incisions or wounds must be completely healed.
  11. . Patients must be at least 12 weeks from the completion of prior radiation therapy (RT)in order to discriminate pseudo progression of disease from progression.
  12. . Patients must be at least 4 weeks from the completion of prior systemic or intracranial chemotherapy.
  13. . For patients who are not receiving therapeutic anticoagulation treatment, an international normalized ratio (INR) and a PTT ≤ 1.5 × the ULN; patients who are receiving anticoagulation treatment should be on a stable dose.

You CAN'T join if...

Patients with any of the following will be excluded from the study:

  1. Prior therapy with Bev.
  2. Any anti-neoplastic therapy, including RT, for first relapse or recurrence.
  3. Evidence of leptomeningeal spread of tumor or any history, presence, or suspicion of metastatic disease extracranially.
  4. Evidence of impending herniation on imaging.
  5. Patients with infections that have required treatment with systemic antibiotics within 7 days of first dose of protocol therapy.
  6. The need for systemic glucocorticoids in doses in excess of 4 mg/day of dexamethasone or in comparable doses with other glucocorticoids.
  7. Treatment with any investigational agents within 5 half-lives of the agent in question or, if the half life is unknown, within 28 days of enrollment.
  8. Pregnant or lactating females.
  9. Prior history of malignancy within 3 years of enrollment other than basal or squamous cell carcinoma of the skin, cervical intra-epithelial neoplasia, in situ carcinoma of the breast, or prostate cancer treated with surgery or RT with a prostate specific antigen of <0.01 ng/mL.
  10. . Patients with active autoimmune diseases within 2 years of enrollment into the study including, but not limited to, rheumatoid arthritis, systemic lupus erythematosus,systemic sclerosis, Sjogren's syndrome, Wegener's granulomatosis, ulcerative colitis,Crohn's disease, myasthenia gravis, Graves' disease, or uveitis except for psoriasis not requiring systemic therapy, vitiligo or alopecia areata, or hypothyroidism; if an autoimmune condition has been clinically silent for 12 months or greater, the patient may be eligible for enrollment.
  11. . Patients on immunosuppressive therapies; the use of topical, inhalational,ophthalmologic or intra articular glucocorticoids, or the use of physiologic replacement doses of glucocorticoids are permitted.
  12. . Patients with primary immunodeficiency diseases.
  13. . Patients with significant bleeding in the preceding 6 months or with known coagulopathies.
  14. . History of abdominal fistula, intestinal perforation, or intra-abdominal abscess in the preceding 12 months.
  15. . Known history of human immunodeficiency virus (HIV) infection, active hepatitis B, or untreated hepatitis C; patients who have completed a course of anti-viral treatment for hepatitis C are eligible.
  16. . Significant cardiovascular disease, including New York Hospital Association Class III or IV congestive heart failure, myocardial infarction within 6 months of enrollment,unstable angina, poorly controlled cardiac arrhythmias, or stroke within the preceding 6 months.
  17. . Any other uncontrolled inter current medical condition, including systemic fungal,bacterial, or viral infection; uncontrolled hypertension; diabetes mellitus; or chronic obstructive pulmonary disease requiring 2 or more hospitalizations in the preceding 12 months.
  18. . Known sensitivity to Bev or any of the components of DSP-7888 Dosing Emulsion.

Locations

  • UCSD- Moores Cancer Center accepting new patients
    La Jolla California 92093 United States
  • Neuro-Oncology/ US Irvine Medical Center accepting new patients
    Orange California 92868 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Boston Biomedical, Inc
ID
NCT03149003
Phase
Phase 2
Study Type
Interventional
Last Updated
September 10, 2018