Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at La Jolla, California and other locations
Dates
study started
completion around
Principal Investigator
by Assuntina Gesualda Sacco, MD
Headshot of Assuntina Gesualda Sacco
Assuntina Gesualda Sacco

Description

Summary

This trial will study tisotumab vedotin to find out whether it is an effective treatment alone or with other anticancer drugs for certain solid tumors and what side effects (unwanted effects) may occur. There are seven parts to this study.

  • In Part A, the treatment will be given to participants every 3 weeks (3-week cycles).
  • In Part B, participants will receive tisotumab vedotin on Days 1, 8, and 15 every 4-week cycle.
  • In Part C, participants will receive tisotumab vedotin on Days 1 and 15 of every 4-week cycle.
  • In Part D, participants will be given treatment on Day 1 of every 3-week cycle. Participants in Part D will get tisotumab vedotin with either:
    • Pembrolizumab or,
    • Pembrolizumab and carboplatin, or
    • Pembrolizumab and cisplatin
  • In Part E, participants will receive tisotumab vedotin on Days 1 and 15 of every 4-week cycle.
  • In Part F, participants will receive tisotumab vedotin on Days 1, 15, and 29 of every 6-week cycle. Participants in Part F will get tisotumab vedotin with pembrolizumab.
  • In Part G, participants will receive tisotumab vedotin on Days 1, 15, and 29 of every 6-week cycle. Participants in Part G will get tisotumab vedotin with pembrolizumab and carboplatin.

Official Title

Open Label Phase 2 Study of Tisotumab Vedotin for Locally Advanced or Metastatic Disease in Solid Tumors

Details

The primary goal of this trial is to assess the activity, safety, and tolerability of tisotumab vedotin for the treatment of selected solid tumors. Patients will be treated with single agent tisotumab vedotin or tisotumab vedotin in combination with other anticancer agents. Patients who meet eligibility criteria will be enrolled into cohorts based on tumor type. Tumor types to be evaluated include colorectal cancer, squamous non-small cell lung cancer (sqNSCLC), exocrine pancreatic adenocarcinoma, and head and neck squamous cell carcinoma (HNSCC).

Keywords

Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Exocrine Pancreatic Cancer, Carcinoma, Squamous Cell of Head and Neck, Colorectal cancer, NSCLC, sqNSCLC, CRC, Pancreatic cancer, Head and neck cancer, Seattle Genetics, HNSCC, Carcinoma, Pancreatic Neoplasms, Non-Small-Cell Lung Carcinoma, Squamous Cell Carcinoma, Squamous Cell Carcinoma of Head and Neck, Carboplatin, Pembrolizumab, Tisotumab vedotin, cisplatin, Tisotumab Vedotin - Q3W Schedule, Tisotumab Vedotin - 3Q4W Schedule, Tisotumab Vedotin - 2Q4W Schedule

Eligibility

You can join if…

Open to people ages 18 years and up

  • Parts A, B, and C
    • Relapsed, locally-advanced or metastatic colorectal or pancreatic cancer, sqNSCLC, or HNSCC participants who are not candidates for standard therapy.
    • All participants must have experienced disease progression on or after their most recent systemic therapy.
    • Colorectal cancer (closed to enrollment): participants must have received prior therapy with each of following agents, if eligible: a fluoropyrimidine, oxaliplatin, irinotecan, and/or bevacizumab. Participants should have received no more than 3 systemic regimens in the metastatic setting.
    • sqNSCLC (closed to enrollment): Participants with NSCLC must have predominant squamous histology. Participants must have received prior therapy with a platinum-based treatment and a checkpoint inhibitor (CPI), if eligible. Participants should have received no more than 3 lines of systemic therapy in the metastatic setting.
      • Participants eligible for a tyrosine kinase inhibitor should have received such therapy. These participants should have received no more than 4 lines of systemic therapy in the metastatic setting.
    • Exocrine pancreatic adenocarcinoma (closed to enrollment): Participants with exocrine pancreatic adenocarcinoma must have predominant adenocarcinoma histology. Participants must have received prior therapy with a gemcitabine-based or 5FU-based regimen, if eligible, and should have received no more than 1 systemic regimen in the unresectable or metastatic setting.
    • HNSCC (closed to enrollment): Participants with HNSCC in Part C must have received prior therapy with a platinum-based regimen and/or a checkpoint inhibitor (CPI), if eligible, and must have experienced disease progression following such therapy. Participants should have received no more than 3 systemic lines of therapy in the recurrent or metastatic setting.
  • Part E
    • Participants with HNSCC must have experienced disease progression on or after their most recent systemic therapy. Participants should have received no more than 1 or 2 systemic lines of therapy in the recurrent/metastatic setting as specified below. Participants must have received a platinum-based regimen and a PD-(L)1 inhibitor.
  • Parts D, F, and G
    • Part D is closed to enrollment. Part F and Part G will enroll only participants with HNSCC.
    • Participants with HNSCC must have received no previous systemic therapy in the recurrent or metastatic disease setting.
    • Part D only
      • Participants with NSCLC must have histologically or cytologically documented squamous cell NSCLC and must have received no previous systemic therapy for metastatic disease or radiation therapy to the lung that is > 30 Gy within 6 months of the first dose of study treatment.
      • PD-L1 biomarker expression as determined by a PD-L1 IHC assay should be available
    • Part F only
      • Participants must have CPS ≥1 by local PD-L1 IHC assay to be eligible for enrollment. Participants must be able to submit a tissue sample for retrospective PD-L1 testing. Tissue may be fresh biopsy or archival, collected within 2 years of Cycle 1 Day 1.
    • Part G only
      • Non-EU eligibility criteria: No CPS requirement for the cohort evaluating tisotumab vedotin in combination with pembrolizumab and carboplatin.
      • EU-specific eligibility criteria: Participants must have a CPS ≥1 by local PD-L1 IHC assay.
      • Participants must be able to submit a tissue sample for retrospective PD-L1 testing. Tissue may be fresh biopsy or archival, collected within 2 years of Cycle 1 Day 1.
  • Baseline measurable disease as measured by RECIST v1. 1.
  • Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 or 1.

You CAN'T join if...

  • Participants with primary neuroendocrine or sarcomatoid histologies. For HNSCC, participants may not have a primary site of nasopharynx or salivary gland.
  • Active bleeding conditions
  • Ocular surface disease at the time of enrollment (Note: cataract is not considered active ocular surface disease for this protocol)
  • Other cancer: known past or current malignancy other than inclusion diagnosis.
  • Uncontrolled tumor-related pain
  • Inflammatory lung disease. Participants with pulmonary disease are allowed if systemic steroids and long-term oxygen are not required
  • Peripheral neuropathy greater than or equal to Grade 2
  • Active brain metastasis
  • Ongoing clinically significant toxicity associated with prior treatment (including radiotherapy or surgery).
  • Part D, F, and G Only: Prior therapy with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor.

Locations

  • UC San Diego / Moores Cancer Center accepting new patients
    La Jolla California 92093 United States
  • Stanford Cancer Center / Blood and Marrow Transplant Program completed
    San Jose California 95124 United States
  • Poudre Valley Health System (PVHS) accepting new patients
    Fort Collins Colorado 80528 United States

Lead Scientist at UCSD

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Seagen Inc.
ID
NCT03485209
Phase
Phase 2 research study
Study Type
Interventional
Participants
Expecting 692 study participants
Last Updated