Niraparib in the Treatment of Patients With Advanced PALB2 Mutated Tumors
a study on Solid Tumor Breast Cancer Breast Tumor Colon Tumor, Malignant Lung Tumor Urologic Cancer Pancreatic Cancer Skin Cancer/Melanoma Metastatic Cancer Esophageal Cancer Endometrial Cancer Head and Neck Cancer PALB2 Mutation Neoplasms Pancreatic Neoplasms Head and Neck Tumor Lung Cancer Colon Cancer Colorectal Tumor
Summary
- Eligibility
- for people ages 18 years and up (full criteria)
- Location
- at La Jolla, California and other locations
- Dates
- study startedestimated completion
Description
Summary
The purpose of this study is to further evaluate the efficacy and safety of niraparib in patients with locally advanced or metastatic solid tumors and a pathogenic or likely pathogenic tumor PALB2 (tPALB2) mutation.
Official Title
A Single-Arm Phase-II Study of Niraparib in Locally Advanced or Metastatic Solid Tumor Patients With PALB2 Mutations
Keywords
Solid Tumor, Breast Tumor, Colon Tumor, Malignant, Lung Tumor, Urologic Cancer, Pancreatic Cancer, Melanoma, Metastatic Cancer, Locally Advanced Solid Tumor, Esophageal Cancer, Endometrial Cancer, Head and Neck Cancer, PALB2, Metastatic Solid Tumor, Advanced Solid Tumor, Local Solid Tumor, PALB2 Mutation, Niraparib, tPALB2, tPALB2 Mutation, Pathogenic tumor, Colon Tumor, Zejula, Neoplasms, Pancreatic Neoplasms, Head and Neck Neoplasms, Esophageal Neoplasms, Endometrial Neoplasms, Neoplasm Metastasis, Breast Neoplasms, Lung Neoplasms, Urologic Neoplasms, Colonic Neoplasms
Eligibility
You can join if…
Open to people ages 18 years and up
- Participants must be at least 18 years of age or older.
- Participants must have a histologically or cytologically confirmed diagnosis of locally advanced or metastatic solid tumor(s).
- Participants must have tested positive for a pathogenic or likely pathogenic tPALB2 gene mutation using a CLIA-certified laboratory as described in the Next-Generation Sequencing (NGS) Laboratory Manual.
- Participants who have stable and asymptomatic Central Nervous System (CNS) disease must be receiving a stable (for at least 7 days) or decreasing corticosteroid dose at the time of study entry.
- Participants must submit fresh or archived (collected within 24 months of enrollment) Formalin-Fixed Paraffin-Embedded (FFPE) tumor sample to the central laboratory for post-enrollment confirmation of tPALB2 status.
- Participants must have received all standard therapies appropriate for their tumor type and stage of disease or, in the opinion of the Investigator, the patient would be unlikely to tolerate or derive clinically meaningful benefit from appropriate standard of care therapy, or the participant has no satisfactory alternative treatments.
You CAN'T join if...
- Participants have other active concomitant malignancy that warrants systemic, biologic, or hormonal therapy.
- Participants who have ovarian or prostate cancer.
- Participants who have variants of undetermined significance (VUS), but not pathogenic variants of PALB2, at the time of screening.
- Participants who relapsed while receiving platinum based therapy in the adjuvant/curative setting.
- Participants progressing within 14-18 weeks while receiving platinum based therapy in the metastatic setting.
- Participants who have received Poly (ADP-ribose) polymerase (PARP) inhibitor(s) in prior lines of treatment.
- Participants with leptomeningeal disease, carcinomatous meningitis, symptomatic brain metastases, or radiologic signs of CNS hemorrhage.
- Participants with germline or somatic BRCA1 or BRCA2 mutations.
- Participant has systolic blood pressure (BP) over 140 mmHg or diastolic BP over 90 mmHg, despite optimal medical therapy.
- Participants have previously or are currently participating in a treatment study of an investigational agent within 3 weeks of the first dose of therapy preceding the study.
- Participants have received prior systemic cytotoxic chemotherapy, biological therapy, or hormonal therapy for cancer, or received radiation therapy within 3 weeks of the first dose therapy preceding the study.
Locations
- University of California San Diego
accepting new patients
La Jolla California 92093-0698 United States - Sharp Healthcare
accepting new patients
San Diego California 92123 United States
Details
- Status
- accepting new patients
- Start Date
- Completion Date
- (estimated)
- Sponsor
- Tempus Labs
- ID
- NCT05169437
- Phase
- Phase 2 research study
- Study Type
- Interventional
- Participants
- Expecting 110 study participants
- Last Updated
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